In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases.

Umbilical cord amniotic bands occur in approximately

What are the novel findings of this work? The performance of combined first-trimester screening in predicting early-onset and preterm pre-eclampsia (PE) is similar when serum levels of pregnancy-associated plasma protein-A and placental growth factor are measured before or after 11 weeks' gestation. What are the clinical implications of this work? Measurement of serum biomarkers for both PE and aneuploidy screening before the first-trimester scan permits risk calculation for both screening tests at the time of the scan without compromising PE screening performance.

Background: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are major causes of maternal and perinatal morbidity and mortality. Previous studies have shown that intervention with low-dose aspirin resulted in a reduction in the occurrence of preterm PE. However, no data are currently available on the effect of low-molecular-weight heparin (LMWH) for the prevention of pregnancy complications in women enrolled at first trimester screening. Objective: We aimed to assess the effectiveness of LMWH in the prevention of PE, IUGR, fetal death, and abruptio placentae in women Low-Molecular-Weight Heparin for Prevention of Preeclampsia 825