Background.
The novel coronavirus severe acute respiratory syndrome coronavirus 2 [coronavirus disease 2019 (COVID-19)] poses unique challenges for immunosuppressed patients. Solid organ transplant (SOT) recipients comprise a large proportion of this group, yet there is limited knowledge about the presentation, clinical course, and immunosuppression management of this novel infection among heart, lung, liver, pancreas, and kidney transplant recipients.
Methods.
We present 21 SOT recipients diagnosed with COVID-19 between January 1, 2020 and April 22, 2020 at a US high-volume transplant center. Diagnostic workup, clinical course, immunosuppression/antiviral management, and immediate outcomes are described.
Results.
Twenty-one (15.9%) of 132 symptomatic patients tested were positive. Mean age at diagnosis was 54.8 ± 10.9 y. Median time from transplant was 5.58 y (interquartile range 2.25, 7.33). Median follow-up was 18 d (interquartile range 13, 30). Fourteen patients required inpatient management, with 7 (50%) placed in the intensive care unit (ICU). All transplant types were represented. Nearly 43% exhibited GI symptoms. Over half (56.2%) presented with elevated serum creatinine suggestive of acute kidney injury. The majority of patients (5/7) with concomitant infections at baseline required the ICU. Eighty percent received hydroxychloroquine ± azithromycin. Ten received toclizumab and/or ribavirin; 1 received remdesivir. Antimetabolites ± calcineurin inhibitors were held or reduced. Over half of hospitalized patients (8/14) were discharged home. Only 1 mortality (4.8%) to date, in a critically ill heart/kidney patient who had been in the ICU before diagnosis.
Conclusions.
COVID-19 positive SOT at our institution had favorable short-term outcomes. Those with concomitant infections had more severe illness. More data will be available to evaluate long-term outcomes and disease impact on graft function.
Abstract:A new radiocarbon laboratory has been established recently at the Lebanese Atomic Energy Commission. This laboratory consists of benzene synthesis line and a low background liquid scintillation counter, Tri-Carb 3180 TR/SL for measurements with Bismuth Germanate (BGO) guard detector. The effectiveness of the benzene line was tested firstly by preparing benzene from a wood sample after carbide and acetylene receiving. Normalization and standardization of the liquid scintillation counter was carried out, as well as the Factor of Merit (E2/B) was determined for three different counting regions. To assure accuracy and reliability of results, reference materials were used. Based on z-score and u-score evaluation, as well as Student's t-test, acceptable data were obtained from travertine and wood samples available through the International Atomic Energy Agency (IAEA-C2 and IAEA-C5), and humic acid (U) and murex shell (R) from the Fifth International Radiocarbon Intercomparison (VIRI). After that, a preliminary study was done, which is the base for future research in order to assess the anthropogenic impact and degree of environmental pollution in terms of radiocarbon isotope ratio (Δ 14 C) deduced from the Percent Modern Carbon or PMC. This work represents the results of four reference materials and those of five green grass samples. The Δ 14 C of green grass samples collected from two different clean zones were found to be 50‰ and 52‰, while the values of those collected from different polluted zones were 23‰, 7‰ and 15‰.
What started around the late 2000s as the "Clean Label" (CL) trend has now become a meaningful segment of the food market, appealing to consumers who want foods made of a limited number of simple and recognizable ingredients.However, this description and tentative definitions of CL foods are vague, subject to multiple interpretations, and CL remains an informal denomination for foods, making consumers' demands and food manufacturers' offerings hardly compatible. Therefore, rather than attempting an illusory definition of CL foods, this narrative review aims to (1) show how CL appears to be a heuristic used by consumers to attempt to make safe and healthful food choices, (2) discuss how this heuristic overlooks many critical aspect of food safety and healthfulness and is consequently ineffective to guide consumers' choices, and (3) discuss the implications of the CL trend on the food chain's stakeholders and their relationships.
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