Introduction: Schizophrenia is a complex clinical syndrome that may present with a great variety of psychopathologic manifestations, covering changes in thought, perception and emotions, as well as motricity and behavioral abnormalities. It symptoms can be divided in positive and negative. Many others psychiatric disturbances share schizophrenia symptoms, among then, Schizoaffective Disorder, with altered mood, as in depression or mania. Although there is, in literature, plenty of evidence about the impact of depressive symptoms in the quality of life in schizophrenic patients, we were unable to identify Brazilian prospects on the subject. Surpassing the findings of other studies, depression in schizophrenic patients has considerable impacts, in addition to its prevalence and frequent underdiagnosis. Objectives: Report a case of patient with Schizoafective Schizophrenia and Depression, treated in the Psycosocial Care Center (CAPES) III in the city of Juazeiro do Norte, Ceará, Brazil. Materials and Methods: Case study, with an descriptive transversal approach, realized under the rules of Resolution 466/12, from National Health Council /National Health Ministry regarding legal and ethical aspects about studies with human beings. The study was registered in the Plataform Brasil, and subsequently forwarded for consideration in the Research Ethics Committee, then being approved.

Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were "Genetic markers", "Mutation", and "Schizophrenia". Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene. KeywordsSchizophrenia, Genetic Markers, Mutations, Systematic Review How to cite this paper: Cardoso, M.A.B.S., do Nascimento, T