BackgroundAntibiotic resistance (AR) continues to be a serious problem. Many factors contribute to AR, including inappropriate use of antibiotics, in which both healthcare professionals and patients play a contributing role. This study aimed to assess the awareness and knowledge of antibiotic usage and AR among the general public (in affluent and deprived areas) and community pharmacists’ (CPs’) in Greater London.MethodsA cross-sectional survey involving members of the public was conducted between July 2014 and February 2015. Stage one involved members of the public (N = 384) residing in affluent areas of London. The second stage targeted public (N = 384) in deprived areas of London. In addition, CPs (N = 240) across the same areas were also surveyed. Data analysis was performed using Microsoft Excel and SPSS Software packages.ResultsResponse rate: 36% (n = 139/384) and 57% (n = 220/384) and 25% (n = 60/240) of public residing in affluent areas, deprived areas and of CPs respectively was achieved. Definitive trends in knowledge of how antibiotics work could not be drawn to distinguish between affluent and deprived areas. However, public respondents residing in affluent areas possessed better understanding of AR and prudent use of antibiotics, and this was statistically significant in both cases (p < 0.05). Exposure to an antibiotic campaign (32% in affluent areas, 17% in deprived areas) did not raise public respondents’ knowledge on AR and only partially raised their general knowledge on antibiotics usage. Only 20% of public residing in deprived areas received counselling from a CP, among them 74% had an antibiotic prescribed on at least one previous occasion. Those who received counselling displayed better knowledge about concordance/adherence with respect to antibiotic usage (p < 0.05) whereas exposure to an antibiotic campaign made no significant impact on knowledge about concordance/adherence.ConclusionThe study highlights that there has been no change in the status quo with respect to awareness of antibiotic usage and AR even after the implementation of several awareness campaigns in England. Those who benefited from CP counselling showed a significant better knowledge towards prudent antibiotic usage which stresses the importance of CPs’ counselling on antibiotic prescription.

Heart disease and cardiovascular disease is a very serious and growing public health issue. Tissue-engineering has great potential and great strength for regeneration, remolding, and growth. In the case of heart failure, Allografting has been used. 3D bioprinting has a great impact in the field of cardiovascular tissue engineering. It has been observed that 3D Bioprinting is used to construct an artificial heart for transplantation and used to create myocardial cells in case of injury. Recent studies showed that biomaterial used in the treatment of myocardial dysfunction is decellularized cardiac extracellular matrix hydrogel in adults. Collagen, Alginate gelatin, hyaluronic acid, and deECM scaffolds were used as biomaterials in 3D bioprinting. It has been shown that scaffold used with ECM was used to support there generation process A new 3D bioprinting technology was developed in which cells were collected into spheroids and printed on a needle array according to desirable characteristics. Different bio inks such as laser, extrusion, droplet, and stereolithography are used here. Electric stimulation is key to the contractility of cardiomyocytes. A physical cardiac replica was created by image processing software that creates 3D structures. In holographic display 3D, full hearts of patients were printed in flexible material. A process is demonstrated to fabricate robust valves of the heart using the3D bioprinting technique. MRI or CT scans were used to obtained 3D images of the aorta.3D bioprinting plays a huge role in knowing the aortic anatomy involves the aortic valve area and morphology of the root. Recent advances demonstrated that 3D bioprinting can assist in ventricular device placement and perform a specific function in a complex with (CHD) Congenital heart defects. 3D bioprinting holds great prom

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