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Chronic kidney disease (CKD) is characterized by a gradual decline in renal function that progresses toward end-stage renal disease (ESRD). Podocytes are highly specialized glomerular epithelial cells which form with the glomerular basement membrane (GBM) and capillary endothelium the glomerular filtration barrier (GFB). GBM is an extracellular matrix (ECM) that acts as a mechanical support and provides biophysical signals that control normal podocytes behavior in the process of glomerular filtration. Thus the modulus of elasticity E or stiffness of

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