Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum. Opponents to this inclusion attribute the important differences and possible diagnostic incomprehension to overlapping symptoms. We tested 248 Borderline and 113 Bipolar patients, consecutively admitted to the Psychiatric Unit, through DSM-IV Axis I and II Disorders (SCID-I/II), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Young Mania Rating Scale (YMRS) and Borderline Personality Disorder Severity Index-IV (BPDSI-IV). All the tests statistically discriminated the disorders (p < 0.0001). Overlapping symptoms resulted significantly different (impulsivity = 5.32 in BPD vs 1.55 in BP, p < 0.0001; emotional instability = 7.11 in BPD vs 0.55 in BP, p < 0.0001) and the range of their scores gives the opportunity for an even more precise discrimination. Distinctive traits (e.g. irritability or sexual arousal) are also discussed in order to try to qualify the core of these disorders to a higher degree. Comorbidity proves to be extremely small (3.6%). However, Borderline patients with manic features offer a privileged point of view for a deeper analysis. This allows for the possibility of a more precise examination of the nature and load of each symptom. Borderline Personality and Bipolar Disorders can be distinguished with high precision using common and time-sparing tests. The importance of discriminating these clinical features may benefit from this evidence.

IntroductionBeta-thalassemia is a monogenic disease caused by mutations in the beta chain of the haemoglobin molecule. It is widespread in many areas of the world and has a large prevalence among Mediterranean populations[1-2]. Furthermore, many studies recently suggested that a gene situated on chromosome 11, proximal to the genes involved in beta-thalassemia, could induce psychosis in predisposed individuals [3]. Several studies have revealed, through the sequencing of chromosome 11, that a possible genetic susceptibility for schizophrenia could be located on the short arm of this chromosome near the gene involved in beta-thalassemia [4-5-6].AimsIn our case report, we describe a late onset of psychosis disorder in a man suffering from beta-thalassemia.MethodsMr. A. is a 35 years old man with a history of major beta-thalassemia treated with transfusion therapy, he is HCV positive. No family history of psychiatric disorders. He has never suffered from any psychiatric disorder until January 2014, when he revealed a psychotic episode characterized by persecution delusions, religious hallucinations, remarkable aggressiveness and absent insight. He was so administrered with Paliperidone Palmitate 100 mg 1 fl 1.m./month, obtaining clinical remission after 5 months.ConclusionSeveral studies have assessed the prevalence of depression and axiety in patients with beta thalassemia. Rather few studies have been conducted to assess the comorbidity of psychosis among beta-thalassemia. We have described one rare case in literature that highlights this possible genetic link between these two pathologies. Further studies are needed to better clarify this association.

Hereditary Angioedema (HAE) is considered an autosomal dominant disorder, characterized by a quantitativeand/or qualitative deficit of C1 esterase inhibitor.