Oral communication abstracts(TVR < 1340 dyn · s · cm −5 , non concentric geometry of the left ventricle) for adverse outcomes of pregnancy. The differential diagnosis of hypertensive disorders in pregnancy is based in clinical, laboratorial and fundoscopic findings. The role of the ophthalmologist in the diagnosis of pre-eclampsia appears to be subjective and limited. Ophthalmic artery Doppler is an objective exam that can improve the diagnosis of hypertension in pregnancy. The study aims to analyze the ophthalmic artery Doppler indices in pregnancies with chronic hypertension and pre-eclampsia. Methods: Cross-sectional study that analysed 30 women with chronic hypertension and 44 preeclamptic women (National High Blood Pressure Education Program 2000 criteria) during the third trimester of pregnancy. Right and left eyes indices means and standard deviation were evaluated to the resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), end diastolic velocity (EDV) and peak ratio (PR). Mann-Whitney test were applied to compare the two groups of hipertensive woman and p-values < 0.05 were considerd statistically significant. Results: The ophthalmic arteries Doppler averages indices in chronic hypertension and pre-eclampsia were respectively RI: 0.74 ± 0.06; 0.63 ± 0.17, PI: 1.68 ± 0.41; 1.12 ± 0.28, PSV: 34.01 ± 10.3; 38.60 ± 9.67, DVF: 9.0 ± 4.12; 14.26 ± 4.74 and PR: 0.64 ± 0.13; 0.82 ± 0.09. The Doppler indices demonstrated ophthalmic artery lower impedance in preeclamptic women compared with chronic hypertension women. All the Doppler indices were accurate in the diferential diagnosis of chronic hypertension and pre-eclampsia demonstrated by p = 0.0001 (RI, PI, EDV, PR) and p = 0.0171 (PSV). The best parameter to establish a cut of point to differentiate chronic hypertension to pre-eclampsia was 0.75 to PR index. OC91 Ophthalmic artery Doppler in the differential diagnosis of hypertensive disorders in pregnancy Conclusions:The ophthalmic artery Doppler is a new parameter that can be used in the differential diagnosis and classification of hypertensive disorders in pregnancy. OC92A proposal for a pharmacological treatment for hypertensive pregnancies complicated by severe fetal growth restriction (FGR) with absent end diastolic flow (AEDF) of the umbilical artery University of Rome 'Tor Vergata', ItalyObjective: Evaluate the effect of nitric oxide (NO) donors and plasma volume expansion (PVE) added to antihypertensive therapy in gestational hypertensive (GH) pregnancies complicated by fetal growth restriction (FGR) with absent end-diastolic flow (AEDF) of Umbilical artery (UA). Methods: 32 GH pregnancies with FGR and AEDF were included into a case-control study. 16 were treated with antihypertensive drugs only (Group B), and 16 were added NO donors, and PVE to the antihypertensive treatment (Group A). All recruited patients underwent fetal and utero-placental assessment, and maternal echocardiographic evaluation calculating total vascular resistance (TVR) and cardiac output (CO) before and af...

Objective: To compare ophthalmic and central retinal arteries Doppler in preeclamptic women with and without visual disturbance and headache. Methods: Transversal study that compared the ophthalmic and retinal central arteries Doppler indices of 40 preeclamptic women with no symptoms compared to 7 preeclamptic women with visual disturbance and headache. Right and left eyes averages Doppler indices were evaluates and resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), end diastolic velocity (EDV) and peak ratio (PR) were calculated. Wilcoxon test was performed to compare the two groups, with significance level of 5%. Results: The main visual disturbance was photophobia. All the seven women referred headache associated with photophobia, and they were not using any medication. Objective: To analyse the preeclampsia influence on the ophthalmic and central retinal arteries Doppler indices. Methods: Case-control study that compared the ophthalmic and central retinal arteries Doppler indices of 40 preeclamptic women (study group) and 51 normotensive pregnant women (control group). The study group was selected using National High Blood Pressure Education Program 2000 criteria. Right and left eyes indices averages were evaluated and the resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), end systolic velocity (ESV) and peak ratio (PR) were calculated. Variance analysis was performed to compare the groups, with significance level of 5%. Results: The ophthalmic and central retinal arteries RI (0.64 ± 0.13; 0.61 ± 0.11) and PI averages (1.08 ± 0.27; 0.82 ± 0.21) were significantly lower (p < 0.0001) in the preeclamptic women when compared to the normotensive pregnant women. The PSV averages of both arteries (37.68 ± 6.31; 10.53 ± 2.91), ESV (13.99 ± 4.09; 4.32 ± 1.73) and PR (0.82 ± 0.08) were significantly higher (p < 0.0001) in preeclamptic women. Conclusion: Preeclampsia was associated with a significant decrease in orbital vascular impedance, observed by the fall in the pulsatility and resistance indices, and elevation of peak systolic velocity, end systolic velocity and peak ratio, indicating orbital hyperperfusion. P15.05The application of logistic regression risk modelling to second trimester uterine artery Doppler screening for pre-eclampsia Objective: To construct a locally-derived risk-adjusted model for prediction of pre-eclampsia (PET) based on patient demographics and individual patient assessment of blood pressure, total peripheral resistance and uterine artery Doppler waveform analysis at 23 weeks. Method: Our study population of 1902 patients were recruited from first trimester. Between 21 to 23 weeks, blood pressure and echocardiographic assessments were performed on each patient and total peripheral resistance (TPR) calculated. Uterine artery Doppler waveforms were assessed. Pulsatility index (PI) and diastolic flow index (DFI : a novel index presented in separate abstract) were calculated and notch status (none/bilateral/unilateral) was recorded. PI, DFI ...

Objectives To evaluate ophthalmic Doppler velocimetry patterns in pregnant women with pregestational diabetes mellitus with and without retinopathy in comparison to pregnant women without gestational intercurrences. Methods This cross‐sectional observational study analyzed Doppler indices of the ophthalmic arteries, including the resistive index (RI), pulsatility index, peak systolic velocity, second peak systolic velocity, peak ratio, and end‐diastolic velocity (EDV), in 3 groups of pregnant women: diabetic with retinopathy (n = 12); diabetic without retinopathy (n = 85); and nondiabetic controls (n = 122). The Kruskal‐Wallis test was used for the statistical analysis with a probability of 95%. Results The mean gestational ages ± SDs of pregnant women with and without retinopathy and nondiabetic controls were 29.1 ± 2.2, 29.7 ± 2.7, and 31 ± 1.0 weeks, respectively, with no significant differences between the groups (P > .099). The mean RI in the group with retinopathy was significantly higher (P = .030) than in the control group, but it did not significantly differ compared to the group without retinopathy (P = .204). The RI in the control group did not differ from that in the group without retinopathy (P = .079). The EDV was significantly lower in the group with retinopathy (P = .015) in relation to the control group, but there were no differences compared to the group without retinopathy (P = .217). Conclusions Pregnant women with pregestational diabetes mellitus and retinopathy had increased vascular impedance in the ophthalmic artery together with a reduction in the EDV, which was probably related to ischemia, thrombosis, and neovascularization of retinal vessels.

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I addition to the fact that Augustine never wrote specifically about mysticism, wemay consider, for instance, the absence in Augustine's time of a systematic character concept of the infused prayer effects which will shape the later Mystical Theology. However, such effects seem to influence the terms used by Augustine: overly an indicative sign of the philosophical, intellectual, and Neoplatonic influence, which leads to a criticism about the similarity of his narrations to the religious experiences described by the mystics themselves, according to the later Christian tradition. This work presents a brief introduction regarding Augustine as a master of Western mysticism, giving it a new Latin and genuinely Christian expression of the Neoplatonic contemplation conceptual structure.