Rev Bras Cir Cardiovasc | Braz J Cardiovasc SurgRev Bras Cir Cardiovasc 2014;29(1):69-77 Leite ACE, et al. -Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis RBCCV 44205-152344205- DOI: 10.5935/1678 Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis Efeitos da terapia periodontal sobre proteína C-reativa e HDL no soro de indivíduos com periodontite ORIGINAL ARTICLE Abstract Objective: To investigate the effects of nonsurgical periodontal therapy on levels of high-sensitivity C-reactive protein in the sera and its association with body mass index and high density lipoprotein in subjects with severe periodontitis.Methods: Sera from 28 subjects (mean age: 34.36±6.24; 32% men) with severe periodontitis and 27 healthy controls (mean age: 33.18±6.42; 33% men) were collected prior to periodontal therapy. Blood samples were obtained from 23 subjects who completed therapy (9-12 months). Oral and systemic parameters such as the number of blood cells, glucose examination, lipid profile, and high-sensitivity C-reactive protein levels accessed by high-sensitivity immunonephelometry assay, were included.Results: Before therapy, in the periodontitis group, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/ dL was statistically lower than in the control group (P<0.0216).After therapy, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/dL was significantly higher (65.22%) (P<0.0339). The mean value for body mass index was statistically lower in subjects with high-sensitivity C-reactive protein <0.3 mg/dL (24.63±4.19), compared with those with high-sensitivity C-reactive protein ≥0.3 mg/dL (28.91±6.03) (P<0.0411). High density lipoprotein presented a mean value statistically higher after therapy (P<0.0027).Conclusion: In systemically healthy subjects with periodontitis, periodontal therapy was associated with decreased levels of circulating high-sensitivity C-reactive protein and increase of high density lipoprotein in serum. The clinical trial was registered at http://www.clinicaltrials.gov.br/, No. RBR-24T799.Descriptors: C-Reactive Protein. Periodontal Diseases. Cardiovascular Diseases. 70Rev Bras Cir Cardiovasc | Braz J Cardiovasc Surg Bras Cir Cardiovasc 2014;29(1):69-77 Leite ACE, et al. -Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis Such damage compromises the function of the periodontal tissues and may result in tooth loss [1]. RevThe chronic and cyclical nature of the periodontal disease provides an opportunity for continuous hematogenous dissemination of periodontal pathogens and, consequently, a direct exposure of blood vessels to these microorganisms and their endotoxins [4]. Hence, the invasion and proliferation of pathogens in specific sites of the host organism, as in periodontitis, may produce tissue damage and subsequent progression of other diseases through a variety of cellular mechanisms [1].C-reactive protein ...

Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far.ObjectivesThe aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and MethodsThe sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. ResultsA significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using non-sensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). ConclusionThe data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.

Periodontitis is an infectious and inflammatory disease of high prevalence worldwide and constitutes a significant oral health problem. It can lead to tooth loss. In addition, the local inflammatory process can cause the release of inflammatory mediators in the bloodstream and, consequently, contribute to the emergence of systemic effects as cardiovascular and diabetic complications. The purpose of this mini review is to alert health professionals about the risk that periodontitis represents for the onset or exacerbation of complications in individuals with type 2 diabetes mellitus and to emphasize that the mechanical treatment of periodontal disease and reestablishment of oral health are essential for the metabolic control of these patients. The periodontal therapy may help to reduce the risk of systemic complications in diabetes patients. Proper dental management should be suggested by health professionals, mainly from physicians to their patients, in order to improve the health conditions in these individuals.

Perfil da condição bucal de idosas do Distrito FederalOral health status of elderly women from the Brazilian Federal District Resumo Os trabalhos realizados no Brasil a respeito das principais afecções bucais dos gerontes

The significant increase in esthetic surgery, especially buccal fat pad reduction, has led to a corresponding increase in lesions and postoperatory after-effects from this surgical procedure. The aim of this study is to discuss the immediate and mediate risks of removing the Bichat ball, as well as describing a clinical study in which this surgical procedure resulted in lesions of the parotid gland and buccal artery, which was confirmed via nuclear magnetic resonance. The facial lesions were remedied via exploratory surgery by opening a new orifice of the glandular duct in the buccal cavity followed by drainage and compressive surgical bandages.