Central precocious puberty occupies an important place in the practice of a pediatric endocrinologist. If the patient reveals signs of premature sexual development, the diagnostic search is aimed at eliminating the tumor origin of both false (peripheral) and gonadotropin-dependent, or central, precocious puberty, as well as gonadotropin-independent forms of premature sexual development. Oncological alertness is important in the work of not only a pediatric endocrinologist, but also a pediatrician. In the treatment of all non-tumor forms of central precocious puberty, drugs of the group of analogues of gonadotropin-releasing hormone are used, which allows to stop the progression of sexual development, reduce the rate of bone maturation and, thereby, increase the final growth of the child. The most common idiopathic variant of central precocious puberty. The article presents a clinical case of observing a patient with an idiopathic variant of central premature sexual development during therapy with a drug from the group of analogues of gonadotropin releasing hormone of prolonged action. The classical course of the idiopathic variant of central precocious puberty with typical diagnostic difficulties in the onset of the disease, good compensation against the background of therapy with a drug from the group of agonists of gonadotropin-releasing hormone and normal puberty 612 months after cancellation of the therapy is demonstrated. The latter is explained by the proven reversibility of the effects of this group of drugs. The description of this clinical case, in the authors opinion, should be of interest to doctors at the local pediatricians and pediatricians working in the medical care departments for children in educational institutions.

Cushings syndrome often develops due to an excessive intake of glucocorticoids with oral, intravenous, intramuscular administration, but it is possible to get a similar complication with intranasal administration. In this article, we present two cases of children who received nasal eye drops with dexamethasone. The use of drugs for 56 months in one case, and 3 years in another led to the formation of a typical clinical picture of the syndrome. The patients showed progressive dysplastic obesity with a moon-shaped face, atrophic skin changes with the appearance of red-violet, crimson stretch marks, and a decrease in the growth rate. There were some peculiarities in the results of laboratory and instrumental examination, due to age-sex characteristics and the duration of taking dexamethasone. According to the totality of anamnestic, clinical and laboratory parameters, instrumental examination, a drug-induced cushingoid syndrome was diagnosed. Subsequent follow-up after discontinuation of the drug confirmed the diagnosis. The presented clinical cases emphasize that the eye drops contain high doses of steroids and can lead to the development of Cushings syndrome, especially in children with intranasal use. When using nasal drops, it should be borne in mind that glucocorticoids will enter the mouth and be absorbed through the gastrointestinal tract. One should take into account the possibility of psychological dependence on such drops and, as a result, uncontrolled consumption by adolescent children.