Platelet-rich plasma (PRP) is a new approach to tissue regeneration and it is becoming a valuable adjunct to promote healing in many procedures in dental and oral surgery, especially in aging patients. PRP derives from the centrifugation of the patient's own blood and it contains growth factors that influence wound healing, thereby playing an important role in tissue repairing mechanisms. The use of PRP in surgical practice could have beneficial outcomes, reducing bleeding and enhancing soft tissue healing and bone regeneration. Studies conducted on humans have yielded promising results regarding the application of PRP to many dental and oral surgical procedures (i.e. tooth extractions, periodontal surgery, implant surgery). The use of PRP has also been proposed in the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with the aim of enhancing wound healing and bone maturation. The aims of this narrative review are: i) to describe the different uses of PRP in dental surgery (tooth extractions and periodontal surgery) and oral surgery (soft tissues and bone tissue surgery, implant surgery and BRONJ surgery); and ii) to discuss its efficacy, efficiency and risk/benefit ratio. This review suggests that the use of PRP in the alveolar socket after tooth extractions is certainly capable of improving soft tissue healing and positively influencing bone regeneration but the latter effect seems to decrease a few days after the extraction. PRP has produced better results in periodontal therapy in association with other materials than when it is used alone. Promising results have also been obtained in implant surgery, when PRP was used in isolation as a coating material. The combination of necrotic bone curettage and PRP application seem to be encouraging for the treatment of refractory BRONJ, as it has proven successful outcomes with minimal invasivity. Since PRP is free from potential risks for patients, not difficult to obtain and use, it can be employed as a valid adjunct in many procedures in oral and dental surgery. However, further RCTs are required to support this evidence.

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This study examined longitudinal relations between early measures of prosocial action in infancy as well as cognitive and social-cognitive abilities, and the sharing behaviour of preschool children. The results reveal relations between delay-of-gratification at 24 months and inhibitory control at 30 months, and children's sharing at 5 years. Moreover, the analyses showed specific relations between distress understanding at 24 months and preschool children's sharing with friends, and a relation between goal encoding at 7 months and sharing with a disliked other at 5 years. Yet, there were no relations between early measures of prosociality in infancy and preschool children's sharing. The results support the view that inhibitory control competencies and social-cognitive abilities play an important role in the early development of prosocial action.

Developmental continuity between infants' understanding of intentional agency (goals, beliefs, and desires) and young children's attributions of moral intentions were studied in a 4-year longitudinal study (N = 77 children). First, goal encoding at the age of 7 months and implicit false belief understanding at 18 months were predictive of children's understanding of an accidental transgressor's moral intentions at the age of 5 years. Second, 24-month-olds' understanding of subjective desires was predictive of children's ability to understand an accidental transgressor's false belief at 5 years. These correlations remained significant when controlling for gender and verbal IQ. These findings support the theory that an early understanding of intentional agency is foundational for moral cognition in childhood.

Introduction The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.