Background Feline obstructive disease of the lower urinary tract (FLUTD) is a common pathologic condition of cats. It can be related to sterile inflammation, which leads to acute impairment of renal function and the accumulation of electrolytes and acid‐base imbalance. Acute‐phase proteins (APPs) are biomarkers of tissue damage from inflammation that assist in monitoring treatment and prognosis. Objective Monitoring the inflammatory processes of obstructive feline lower urinary tract disease through the determination of plasma fibrinogen concentrations and serum concentrations of the acute‐phase proteins, serum amyloid A (SAA), alpha‐1‐acid glycoprotein (AGP), and albumin. Methodology Twenty‐five male cats were included in this study. They were divided into two experimental groups: a control group (CG) and an obstruction group (OG). There were 8 healthy cats in the CG group and 17 cats with obstructive FLUTD in the OG group. APP measurements were conducted using ELISA kits. Samples were collected for APP analyses, serum biochemical assays, urinalyses, and urine protein: creatinine ratio calculations at diagnosis, before urethral clearance (H0), and 12 (H12), 24 (H24), and 48 (H48) hours after urethral clearance from cats in the OG group. Samples were collected once from cats in the CG group cats. Results At H0, we found positive correlations of SAA, AGP, and fibrinogen with urea and creatinine, and negative correlations of albumin with hematuria, SAA, and potassium. At H48, we found positive correlations between SAA and AGP, AGP and urea, fibrinogen and urea, fibrinogen and creatinine, fibrinogen and AGP, and fibrinogen and SAA. In addition, a negative correlation of albumin with urea and creatinine was observed. Conclusions Serum amyloid A, AGP, fibrinogen, and albumin could be used as biomarkers of inflammatory processes in cats with obstructive FLUTD.

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Background: Ovarian torsion is a condition which the ovary and the ovarian pedicle twist around the ovary suspensory ligament. No report regarding this condition was reported. The aim of the report was to describe a case of unilateral ovarian torsion in a 2-year-old primipara Golden Retriever dog.Case: A 2-year-old female primipara Golden Retriever dog weighting was referred to the Veterinary Hospital, for purulent vaginal discharge evaluation. The dog was presenting anorexia, weight loss, and intermittent diarrhea and vomiting. A cesarean section was performed nine months before her presentation and the oestrus cycle was recorded six months after the cesarean section. Discomfort was observed during the palpation of the abdomen and purulent vaginal was observed. Vaginal swab was performed and followed by cytological examination. The ultrasonographic examination was consistent with pyometra. The ovariohysterectomy was performed and were observed torsion of the left ovary. The histopathological examination of the left ovary and uterus were consistent with ovary necrosis and pyometra. Ten days after surgery the vaginal discharge had resolved and the sutures were removed. Six months postoperatively the dog revealed no further abnormalities. Grossly, the left ovary had firm consistency, dark red surface and 8 cm diameter. The histopathology examination findings were consistent with a diagnosis of diffuse necrosis of left ovary due to ovarian torsion, and uterinesuppurative inflammatory process - pyometra.Discussion: Ovarian torsion is uncommon in small animals, but can be observed high incidence in pregnant female dogs than in non-pregnant ones. The 360º an asynchronous ovarian torsion described in the present case is also an unusual condition in primipara female dogs due to the smaller stretching of the ovary suspensory ligament. The ovarian torsionis considerate an emergency condition due to acute abdominal pain. The mild abdominal discomfort observed during the physical examination was associated to pyometra or to ovarian torsion. The histopathological findings as hemorrhage, edema and necrosis were associated to compromised arterial circulation and ovarian torsion in late stage. The size of the pregnant uterus and/or the pyometra has contributed to ovary torsion. The dog of the present report had pyometra and previouscesarean sections; and these conditions may have contributed to ovarian torsion. The condition was incidentally found during the ovariohysterectomy, and the ovarian torsion diagnosis was determinate through histopathological examination. Computed tomography and magnetic resonance image could be used to diagnose, furthermore, they were not conducted due to the high cost. The leukocytosis and red blood cells Rouleaux was associated with ovarian necrosis and pyometra.Ovariohysterectomy was the treatment of choice to pyometra and ovarian torsion, and the surgery was performed without ovarian torsion reversion to minimize the reperfusion lesions. Ovarian torsion is a rare event in dogs, and it was clinically diagnosed during the surgery. To the best of the authors’ knowledge, this is the first report of ovarian torsion associate withpyometra in primipara female dogs in Brazil.Keywords: dog, obstetric, ovary, pyometra complex, endometrium.

This study aims at assessing the prevalence of glomerular alterations in dogs with chronic kidney disease (CKD) and comparing the clinical and laboratory parameters. The tests conducted include a double-blind histopathological assay conducted by two pathologists, urine tests including inactive sediment, urinary protein-to-creatinine (UPC), serum albumin and serum creatinine, as well as measurement of the systolic arterial blood pressure. The prevalence of glomerular injuries was determined and the predominant injury was compared with a group comprised of the remaining injuries. The study included 24 dogs with CKD. The results revealed a predominance of membranous glomerular alterations 17/24 (70,83%), followed by glomerulosclerosis 3/24 (12,50%), membranoproliferative injuries 2/24, glomerulocystic atrophy 1/24 and glomerular amyloidosis 1/24. Amyloidosis presented the highest UPC while the membranoproliferative injury presented the lowest mean concentration of serum albumin. Higher values in the UPC did not correspond with lower mean serum albumin values. Glomerulosclerosis presented the highest mean systolic blood pressure and glomerular atrophy presented the highest creatinine values. When comparing membranous injuries with a group comprised of the remaining injuries, the UPC did not present significant differences between the groups. Renal amyloidosis was included in the group with the lowest systolic arterial blood pressure values while membranoproliferative injury was included in the group with highest UPC. The group called “others” presented the highest creatinine value. Dogs with CKD may present several types of glomerular injuries with similar clinical and laboratory profiles. This study observed a predominance of membranous glomerular injuries, followed by membranoproliferative injuries, glomerulocystic atrophy and amyloidosis.

Background: Adjustable nylon ties polyamide 6.6 is devices produced from the same material of surgical nylon wire and have been used in different surgical procedures in small animals and in human patient. Reports regarding the use of these devices as secondary fixation technique of femoral diaphyseal fractures in animals are rare in the literature. The aim of the present report case was to describe the use of adjustable nylon tie polyamide 6.6 as secondary fixation technique in a 3-year-old dog and 4-month-old cat, diagnosed with femoral diaphyseal fractures.Cases: Case 1. A 3-year-old female dog was presented with reluctance to support the left hind limb, with 5 days’ duration. Pain and edema on the left femoral diaphyseal region was identified. The limb was submitted to radiographic exam and revealed a closed, complete and comminuted fracture of the diaphysis of the femur, and was decided to perform a surgical stabilization by open reduction through primary fixation with intramedullary pin, and secondary fixation of bone fragments with adjustable nylon ties polyamide 6.6, as a substitute of steel cerclage wire. The bone fragments were alignment and fixated with five polyamide nylon ties. The excess was removed with a scalpel blade along the lock. Seven days after surgery the skin sutures were removed and were observed reluctance to support the left hind limb. Physiotherapy sessionswere prescribed. Forty days after the surgery was performed a radiographic exam of the left hind limb which revealed alignment of the bone axis. Six months after the surgery, the owner reported that the dog supported the left hind limb.Case 2. A 4-month-old female cat was presented with history of trauma, with 24 h’s duration, and reluctance in supporting the left hind limb. On physical examination there was identified pain on the left femoral diaphyseal region. Radiographic examination revealed a closed, complete and simple fracture of the diaphysis of the femur, and a surgical stabilization through primary fixation with intramedullary pin, and secondary fixation with three polyamide nylon ties was performed.Seven days after the surgery were observed reluctance to support the left hind limb. Three months after the surgery, the owner was contacted and he reported that the cat was supported the limb.Discussion: Adult dogs are more susceptible to diaphyseal fractures and so does the dog in the present report. On the other hand, young cats present high metaphyseal fracture rates due to the metaphyseal growth plate. However, the cat in the present report was different since it was 4-month-old and presented diaphyseal fracture. Different from steel cerclagewires, polyamide nylon ties were used as secondary fixation in diaphyseal fractures for the reason that of their stability in this kind of fracture, no tissue reaction and minimal tissue trauma. The adjustable nylon ties polyamide 6.6 were already used in different surgical procedures in human patients and animals. Complications reported in the literature due to theiruse were associated with erroneous surgical techniques. Adjustable nylon ties polyamide 6.6 proved to be efficient as bone cerclage device in diaphyseal multiple and simple fracture, as well as gave stability to the herein assessed adult dog and young cat, besides not inducing foreign body reactions.Keywords: small animals, polyamide, bones, cerclage, surgery.