Background Variants of the estrogen receptor b (ESR2) gene have been associated with different types of cancer. However, these associations have been inconsistent. We genotyped the ESR2 variants (rs1256049, rs4986938, and rs1256030) in breast cancer (BC) patients and in healthy women. Results The variants rs1256049 and rs4986938 in the ESR2 gene were not associated with risk susceptibility in BC patients. However, the rs1256030 variant had an association as a risk factor for BC patients when compared with controls and BC patients for the TT genotype (odds ratio (OR) 1.86, 95% confidence intervals (CI) [1.05–3.28], p = 0.042). In addition, differences were observed in patients and controls carrying the TT genotype under 50 years of age (OR 1.85, 95% CI [1.05–3.27], p = 0.043). Thus, evident differences showed the rs1256030 variant in patients with TT, TC, and TC+TT genotypes with: (1) Stage IV (OR 1.60, 95% CI [1.06–2.54], p = 0.033), and (2) Luminal A (OR 1.60, 95% CI [0.47–0.21], p = 0.041), as well as in BC carriers of the TT genotype with indices of cellular proliferative (Ki-67) elevated (>20%) and overweight (OR 1.67, 95% CI [0.85–3.28], p = 0.041), respectively. In BC HER2 with lymph node metastasis, the TT genotype was a protective factor (OR 0.38, 95% CI [0.18–0.78], p = 0.005). The identification of haplotypes included two common GAT as risk factors (OR 3.1, 95% CI [1.31–7.72], p = 0.011) and GGC as a protective factor (OR 0.7, 95% CI [0.60–0.97], p = 0.034). The haplogenotype GGGATC was a risk factor (OR 2.5, 95% CI [1.28–5.0], p = 0.008). Conclusion The variant rs1256030 (TT) of the ESR2 gene and haplotype GAT were associated with susceptibility to BC as risk factors in this sample from the Mexican population.

Psychoneuroendocrinoimmunology is the area of study of the intimate relationship between immune, physical, emotional, and psychological aspects. This new way of studying the human body and its diseases was initiated in the last century’s first decades. However, the molecules that participate in the communication between the immune, endocrine, and neurological systems are still being discovered. This paper aims to describe the development of psychoneuroendocrinoimmunology, its scopes, limitations in actual medicine, and the extent of melatonin within it.

Introduction: The MDM2 gene plays an important role as negative regulator of the p53 tumor suppressor. Data on polymorphisms in the MDM2 gene have revealed associations with cancer, particularly for the rs2279744 promoter polymorphism (309 T > G), which attenuates the P53 pathway and promotes tumorigenesis in the mammary gland. Material and Methods: We examined the role of the MDM2 309 T > G polymorphism through a comparison of the genotypes of 408 healthy Mexican women with those of 529 Mexican women with breast cancer (BC). Results: The genotype frequencies of the MDM2 309 T > G polymorphism in controls and BC patients were 25% and 23% for T/T (wild type), 50% in BC and controls for T/G, and 25 and 27% for G/G (polymorphic type), respectively. The obtained odds ratio (OR) was 1.07, with a 95% confidence interval (95% CI) of 0.79-1.45, p = 0.64 for the T/G-G/G genotypes. The association was evident when the distributions of the G/G genotypes in patients exhibiting the following characteristics were compared: breastfeeding >6 months (OR 2.1, 95% CI 1.3-3.4, p = 0.002), obesity (OR 1.8, 95% CI 1.2-2.7, p = 0.003) and high GGT levels (OR 1.7, 95% CI 1.1-2.5, p = 0.012). The genotype G/G of the MDM2 309 T > G. Conclusions: The MDM2 309 T > G polymorphism was associated with BC susceptibility, particularity in breastfeeding, obesity and high GGT levels in the analyzed Mexican population.