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<p><strong>Introduction</strong>: bacterial infections are a public health problem. Besides, the emergence of strains resistant to antimicrobials has<br />contributed to the search for new alternatives, such for the terpenes with antimicrobial potential. <strong>Objectives</strong>: the objective of this<br />study was to determine the possible interaction of isolated monoterpenes (-)-Carveol, Geraniol, Citronellol, α-terpineol, R-(-) Carvone,<br />(-)-Menthol, Linalool, D-Dihydrocarvone, and (-)-Terpine-4-ol with conventional antimicrobials (Chloramphenicol, Minocycline,<br />Amoxicillin and Ciprofloxacin) when they are evaluated on Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis,<br />Escherichia coli and Pseudomonas aeruginosa strains. <strong>Methodology</strong>: the minimum inhibitory concentrations of these test drugs<br />were determined using the microdilution method. The Checkerboard method was used to assess the interactions, by determining<br />the fractional inhibitory concentration index (FIC index). <strong>Results</strong>: aamong the monoterpenes, only Carveol, Citronellol, and Geraniol<br />presented antimicrobial activity (MIC &lt; 1024 μg/mL). They presented synergistic effects against Pseudomonas aeruginosa ATCC-9027<br />(FIC index ≤ 0.5) when in combination with Minocycline. <strong>Conclusion</strong>: this study contributes to the development of new approaches<br />to control bacterial resistance and to the possibility of discovering new drugs.</p>