Mechanical neck pain has a lifetime and point pre valence almost as high as low back pain 31 and results in substantial disability and economic burden for society. 29 The authors of a recent study 16 found that the prevalence of mechanical neck pain has decreased in the last few years in Spain, potentially attributed to a better understanding and management of the condition. Physical therapy is usually the first management option for individuals with insidious-onset mechanical neck pain. T T METHODS: Seventeen patients (53% female)were randomly assigned to 1 of 2 groups: a single session of TrPDN or no intervention (waiting list). Pressure pain thresholds over the C5-6 zygapophyseal joint, second metacarpal, and tibialis anterior muscle; neck pain intensity; and cervical spine range-of-motion data were collected at baseline (pretreatment) and 10 minutes and 1 week after the intervention by an assessor blinded to the treatment allocation of the patient. Mixed-model analyses of variance were used to examine the effects of treatment on each outcome variable. T T RESULTS: Patients treated with 1 session ofTrPDN experienced greater decreases in neck pain, greater increases in pressure pain threshold, and higher increases in cervical range of motion than those who did not receive an intervention at both 10 minutes and 1 week after the intervention (P<.01 for all comparisons). Between-group effect sizes were medium to large immediately after the TrPDN session (standardized mean score differences greater than 0.56) and large at the 1-week follow-up (standardized mean score differences greater than 1.34). T T CONCLUSION:The results of the current randomized clinical trial suggest that a single session of TrPDN may decrease neck pain intensity and widespread pressure pain sensitivity, and also increase active cervical range of motion, in patients with acute mechanical neck pain. Changes in pain, pressure pain threshold, and cervical range of motion surpassed their respective minimal detectable change values, supporting clinically relevant treatment effects. Therapy, level 1b-. J Orthop Sports Phys Ther 2014;44(4):252-260. Epub T T LEVEL OF EVIDENCE: