Objectives: This study examined data on multidimensional functioning in a group of individuals with Smith-Magenis syndrome (SMS). Methods: Parents of 19 children, adolescents, and young adults with SMS were interviewed on developmental, physical, medical, behavioral, and social-communicative aspects. Results: The data presented here provided relevant neurodevelopmental information, and focused not only on problems and deficits, but also on areas of relative strength, particularly social. Discussion: Our study contributed to further the understanding on the prevalence of a broad set of characteristics in a sample of individuals with SMS from a wide age range.