IntroductionThe importance of monitoring MetS in people with schizophrenia has been reiterated by consensus panels throughout the world. However, health screening remains limited.ObjectivesThe NB MetS Protocol was developed to address the needs of this population by monitoring metabolic risk factors.AimsThe relationship between MetS, subjective quality of life (QoL) and global functioning were examined. The MetS Protocol enabled us to participate in a group of experts in schizophrenia. This meeting resulted in a Catalan Consensus Statement.MethodsThe MetS Protocol was set up by adapting the resources of the community mental health team, without specific additional funding. For our goal, 76 patients with schizophrenia and schizoaffective disorder were interviewed to obtain sociodemographic data, lifestyle habits, psychopathology (PANSS), global functioning (GAF), subjective QoL (EQ-5D) and the anthropometric measures and blood test results. MetS was defined by the NCEP criteria.ResultsThe prevalence of MetS was 36.8% and was correlated with higher body mass index (BMI), older age, inactive employment status and better self-care (due to increased awareness of self-image). Patients with MetS who engaged in physical activity reported a subjective perception of better health.ConclusionsIt is well known that there is no specific best model, but national guidance should be adapted to meet local needs. This has implications for treatment planning at the individual and organizational levels in order to improve the subjective QoL of the patients. The future plan is to develop individualized lifestyle programs for high-risk individuals identified with metabolic syndrome.

Author's Contributions LPS: performed data analyses, interpreted results, and drafted manuscript; MN: assisted with data analysis; PM: designed and carried out animal trial, and collection of samples; JS: directed RNA extraction and sequencing; MA: directed RNA extractions and sample collection; MHP: designed the animal trial; MSD: developed RNA-seq study and interpreted results; NVLS: developed RNA-seq study, data analyses, interpretation of results, and drafted manuscript. All authors read and approved the final version of the manuscript.