Background. Considering the scope and magnitude of the National Unified Health Research Agenda (NUHRA), the implementation of the agenda requires adequate planning. Reviewing the implementation of the first and second versions of NUHRA, implemented from 2006 to 2010 and from 2011 to 2016 respectively, is thus useful in identifying potential challenges for implementing the current version. Objectives. This article aimed to 1) describe strategies employed in the previous NUHRAs,2) describe uptake of the previous NUHRAs; and 3) identify lessons learned from the implementation of NUHRA 1 and 2. Methods. Review of the NUHRA 1 and 2 evaluation reports and minutes of PNHRS Research Agenda Committee meeting was conducted. Interviews with PCHRD division head and staff and representatives from the academe and regional consortia were also conducted. Results. A total of 96 of the 422 NUHRA 1 priorities were implemented, while 45 of the 56 NUHRA 2 priorities were implemented. While NUHRA 1 implementation was delegated to numerous agencies, dissemination was conducted primarily by PCHRD through launch events and fora. Implementation of the NUHRA 2 was delegated only to the four core agencies of the PNHRS, with each agency employing different strategies for the dissemination of the NUHRA 2. Conclusion. Involvement of agencies beyond the core of PNHRS may be the better direction for implementation of the current NUHRA. Strong support and commitment of the core agencies will be key in the effective implementation of the NUHRA.