Objectives There is conflicting evidence about the utility of statins use on clinical outcomes in patients with coronavirus disease 2019 (COVID-19). We performed a systematic review and meta-analysis to examine the effect of statins use on mortality in COVID-19 patients. Methods We searched electronic databases from inception to March 3, 2021. We pooled unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) using random-effects models. Results Twenty-five cohort studies involving 147824 patients were included. The mean age ranged from 44.9 to 70.9 years and 57% of patients were men. The use of statins was not associated with mortality using unadjusted risk ratio (uRR, 1.16; 95% CI, 0.86-1.57, 19 studies). In contrast, meta-analyses of adjusted odds ratio (aOR, 0.67; 95% CI, 0.52-0.86, 11 studies) and adjusted hazard ratio (aHR, 0.73; 95% CI, 0.58-0.91, 10 studies) showed that statins were independently associated with a significant reduction of mortality. Subgroup analyses showed that only chronic use of statins significantly reduced mortality according to the adjusted models. Conclusions The use of statins was associated with a lower risk of mortality in COVID-19 patients based on adjusted effects of cohort studies. However, randomized controlled trials are still needed to confirm these findings.

Introducción: La actual pandemia por un nuevo coronavirus (SARS-Cov-2) ha cobrado la salud y la vida de muchas personas mundialmente. Esto genera un impacto negativo en la salud mental del personal de salud, lo cual incluye a estudiantes de medicina. Objetivo: Determinar el grado de ansiedad presente en estudiantes de medicina del primer año de una universidad privada, Lima-Perú. Métodos: La muestra estuvo conformada por 57 estudiantes de una universidad privada en Lima-Perú. Se aplicó la escala para medir el Desorden de Ansiedad Generalizada-7 (GAD-7). Los datos fueron analizados mediante tablas de frecuencias y de contingencia, además se realizó el análisis bivariado aplicando las pruebas estadísticas X2 y T de Student. Resultados: El 75,4% de los estudiantes de medicina manifestaron algún grado de ansiedad. Se encontró asociación estadísticamente significativa entre el sexo femenino y ansiedad (p = 0,045). Así mismo, no hubo asociación entre las variables edad y ansiedad (p = 0,058). Conclusión: Los estudiantes de medicina de primer año evidenciaron niveles altos de ansiedad durante la actual pandemia, siendo las mujeres entre quienes la ansiedad se presenta con mayor frecuencia. Se hace oportuno el desarrollo de estrategias de intervención en los centros universitarios para el cuidado de la salud mental de los estudiantes de ciencias de la salud.

Background Coronavirus disease 2019 (COVID-19) remains a public health problem worldwide. There is conflicting evidence about the impact of statins use on clinical outcomes in patients with COVID-19. Purpose We performed a systematic review and meta-analysis to assess the effect of statins use on mortality in these patients. Methods We searched electronic databases from inception to March 3, 2021 for cohort studies evaluating the association between chronic and/or inpatient use of statins and mortality. Risk of bias was assessed using the Newcastle-Ottawa Scale. We pooled unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) using random-effects models. Results A total of 25 cohort studies involving 147824 patients were included. The mean age ranged from 44.9 to 70.9 years and 57% of patients were men. The use of statins was not associated with mortality according to the unadjusted risk ratio (uRR, 1.16; 95% CI, 0.86–1.57, 19 studies). In contrast, meta-analyses of adjusted odds ratio (aOR, 0.67; 95% CI, 0.52–0.86, 11 studies) and adjusted hazard ratio (aHR, 0.73; 95% CI, 0.58–0.91, 10 studies) showed that the use of statins was independently associated with a significant reduction of mortality. Adjusted confounders included age, sex, and cardiovascular comorbidities in most of cohorts. Eighteen studies were scored as low risk of bias, six studies as moderate risk of bias, and one study as high risk of bias. Conclusion The use of statins was associated with lower mortality in patients with COVID-19 based on adjusted effects of cohort studies. However, randomized controlled trials are needed to confirm these findings. Funding Acknowledgement Type of funding sources: None.

Aims: The aim of this study is to determine the proportion of anxiety in Spanish medical students during the COVID-19 pandemic. Methodology: 31 undergraduate medical students from a Spanish university answered an on-line questionnaire in April 2020. The GAD-7 scale was used to measure anxiety levels, and the presence of probable anxiety was calculated with cut-off points. Results: Anxiety was observed in 64.5% of the sample, being more common among women and younger students. Conclusions: The proportion of anxiety found in the sample highlight the urgent need to evaluate anxiety symptomatology in medical students during the COVID-19 pandemic and to stablish adequate psychological support programs. Future epidemiological studies with large and representative samples are warranted to surveille mental health in this population. Objetivos: El objetivo de este trabajo es determinar la proporción de ansiedad en estudiantes españoles de medicina durante la pandemia de COVID-19. Metodología: 31 estudiantes del grado de medicina de una universidad española contestaron un cuestionario on-line en abril del 2020. La escala GAD-7 se utilizó para evaluar sintomatología ansiosa autorreportada, y se utilizaron los puntos de corte para clasificarlos en ansiedad probable. Resultados: El 64,5% de la muestra presentó ansiedad, siendo más prevalente entre mujeres y los más jóvenes. Conclusiones: La prevalencia de ansiedad en la muestra analizada sugiere la necesidad de evaluar sintomatología ansiosa entre los estudiantes de medicina durante la pandemia de COVID-19 y establecer programas de apoyo psicológico adecuados. Estudios epidemiológicos futuros con muestras amplias y representativas se hacen necesarios para hacer un seguimiento de la salud mental de este colectivo.