1 The mechanisms underlying stimulation of bladder contractions and bronchoconstriction by the selective NK2 receptor agonist, L6-Ala8]NKA(4-10), were examined in the anaesthetized guinea-pig.2 Atropine, a,f-methylene-ATP and ganglion blocking agents were used to examine the contribution of reflex arc activation and/or potentiation of efferent mechanisms to the NK2 receptor-mediated responses seen in these two tissues.
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