Objective: Characterize clinically and epidemiologically patients with von Willebrand disease and abnormal uterine bleeding. Methods: A cross-sectional descriptive observational study was carried out. The study population was women with a diagnosis of von Willebrand’s disease who consulted in a highly complex institution in the city of Medellín. The analysis was carried out through the SPSS V 24 program. Results: 70 patients were included, 50 of these were discarded because they did not present abnormal uterine bleeding or had other diagnoses that could intervene in the characterization as antiphospholipid syndrome. The median age of the included patients was 19.5 years (Min: 11, Max: 52). 9 patients (60%) used contraceptive methods, the reported methods were combined oral contraceptives (26.7%), intrauterine devices (20%) and surgical methods (13.3%). Regarding the clinical characterization, it was found that the most frequent manifestations were the presence of bruises 40% (8) and epistaxis 40% (8). Most of the patients, 65% (13) had not received treatment for abnormal uterine bleeding. Laboratory tests showed the following: hemoglobin 13 g/dL (6.6 - 15.7), hematocrit 37.5% (20.3 - 46.1), platelets 279,000 cells/mm3 (106,000 - 393,000), von Willebrand factor plasma antigen 68.5 IU (19.7 - 205), von Willebrand factor plasma activity 44 IU (23 - 126). Conclusion: Abnormal uterine hemorrhage is a frequent manifestation in women with von Willebrand disease and can present at different stages of life, despite its diagnosis, women do not receive management of this clinical manifestation until their consultation with gynecology. Key words: von Willebrand Diseases, von Willebrand Factor, Abnormal uterine bleeding, Metrorrhagia.

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