Between 20-40% of patients with multiple myeloma (MM) present with renal impairment (RI) at diagnosis (Korbet & Schwartz, 2006; Kastritis et al., 2007) and up to 10% of them require dialysis (Dimopoulos et al., 2010). Prognosis in these patients remains significantly worse when compared with patients with normal renal function (Haynes et al., 2010). Daratumumab is an anti-CD38 IgG kappa human monoclonal antibody that has demonstrated superior clinical benefit across lines of therapy, either as monotherapy or when combined with standard-of-care regimens for the treatment of patients with relapsed and refractory MM (RRMM) (Usmani et al., 2016; van de Donk et al., 2016). However, data of daratumumab in patients with RRMM and dialysis-dependant renal failure are lacking. We report the efficacy and safety results from a retrospective Spanish study of daratumumab in patients with RRMM and end-stage RI requiring dialysis. Methods M.J.C. performed the research and contributed to analyzing of data and paper writing. J.D.L.R. was involved in designing the study, analysis, interpretation and reporting of the data, and wrote/reviewed the paper. All authors performed the research and reviewed the draft manuscript and approved the final version for publication.

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Provincial de Badajoz cuenta entre su colección con una singular escultura romana que, por su iconografía, puede ser identificada como la representación de un dios Lar pero cuyo material y dimensiones hacen de ella una pieza sin paralelos conocidos hasta la fecha. La singularidad de ambas características la convierte en objeto de un particular interés en el estudio y la comprensión del culto doméstico romano en general y, concretamente, en Hispania. SUMMARY The Provincial Archaeological Museum of Badajoz includes in its Roman art collection a singular sculpture which, due to its iconography, can most probably be identified as the representation of a Lar. However, the fact that it was sculptured in marble and its large dimensions make it a piece unparalleled till now. These two singular features highlight the particular interest of this sculpture for the study and understanding of the Roman domestic cult, particularly in Hispania.

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A 3 4 7 -A 7 6 6 methods to convert US SF-36 scores into French utility scores. Methods: US scores were obtained from EVEREST II REALISM HR, a prospective, multi-center, continued access study on "real world" use of MitraClip in high risk patients. The three methods to estimate utilities are: A) convert SF-36 into EQ-5D using Gray algorithm, then EQ-5D in French utilities using Chevalier algorithm, B1) convert SF-36 into UK utilities using Gray algorithm, and B2) convert SF-36 into UK utilities using Rowen algorithm. Graphical comparisons, Bland-Altman graphs, and intraclass correlation coefficient were used. Results: During one year, 1931 SF-36 questionnaires were collected among 618 patients. Moderate correlation between algorithms and differences in metric properties were observed. Due to limited number of states, EQ-5D step leaded to discontinuity. Due to two-part algorithm, a ceiling effect with saturation at value 1 was observed for algorithm B1. Intraclass correlation coefficient between A and B1 was 0.565 and between A and B2 was 0.614. Bland-Altman graphs showed more differences for small values. ConClusions: Algorithm A, via EQ-5D conversion, was preferred because its result is in French utility scores, despite some considerations in metric properties. Algorithm B2, without ceiling effect but in UK scores, was used as sensitivity analysis. Nevertheless, there is a remaining uncertainty as EVEREST II REALISM HR patients were not French. That analysis suggests that SF-36 mapping methods should be developed in French patients.