COVID-19 is a respiratory disease caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of this infection on fetal development and whether there is vertical transmission are currently unknown. We present two cases of pregnant women with COVID-19 infection during the first and second trimester of gestation in which a PCR study of SARS-CoV-2 in amniotic fluid extracted by amniocentesis is performed to try to determine if there is vertical transmission. In both cases, the PCR result was negative. This fact could support the absence of vertical transmission when the infection occurs in these quarters. It would be advisable to carry out more extensive studies to be able to make this statement safely.

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Objective: Determine the strengths and weakness of asymptomatic screening for COVID-19 in pregnant women. Analyze the results an percentage of positives in asyntomatic pregnant women. Design: Descriptive retrospective observational study. Setting: Mancha-Centro Hospital (Spain). Population: Asymptomatic pregnant women that get in to the hospital. Methods: Between the 12th of April and 1th of June 2020, all the asymptomatic pregnancies were screened with diagnostic test for SARS-CoV-2. Data collection was done by reviewing the medical records. Main outcomes measures: Clinical characteristics, management, treatment, and obstetric and neonatal outcomes. Results: A total of 117 patients were routinely screened using serological tests in maternal blood and PCR in nasopharyngeal exudate to detect COVID-19 patients. Of the 117 patients screened, 24 (20.5%) were positive in at least one of the two tests used for screening, of which 19 (79%) were asymptomatic and 5 (21%) symptomatic. Conclusions: We recommend universal screening of all pregnant woman for COVID-19 during the pandemic because of the limits of the symptomatic screening seen in the actual literature and the importance of transmission between asymptomatics patients.