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The earthquake sequence started on May 20th 2012 in Emilia (Italy) affected a region where masonry constructions represent a large part of the existing building stock and the construction of new modern masonry buildings is a common practice. The paper is focused on the performance of common architectural configurations, typical for residential or business use. The large majority of old masonry buildings is made of fired clay bricks. The seismic performance of these buildings is particularly interesting since major past earthquakes in Italy affected areas with mainly stone masonry structures. Apart from examples showing systematic or peculiar structural deficiencies governing the vulnerability of several buildings, the overall seismic performance of these structures to repeated shaking, with PGA as large as 0.25–0.3g was rather good, despite the major part of them were only conceived for carrying vertical loads. In fact, seismic design is mandatory in the area only since 2003. Modern low-rise masonry buildings erected after this date and incorporating seismic design and proper detailing resulted in most cases practically undamaged. The examples reported in the paper allow an evaluation of the superior performance of seismically designed modern masonry buildings in comparison to older ones