PSLS although diminished in both groups with CAD was lower in diabetics at all DSE stages, and DM was an independent predictor of this impairment. However, the dobutamine challenge did not deepen the resting differences, suggesting that the direct impact of coronary stenoses effaces the influence of DM during DSE. The comparison with our previous data revealed synergistic, detrimental effect of coexisting CAD and DM on myocardial strain.

ORIGINAL ARTICLE Effect of sex on the diagnostic efficacy of dobutamine stress echocardiography... 105INTRODUCTION Coronary artery disease (CAD) and its complications remain the leading cause of premature mortality in men and women. Diagnosis and treatment of CAD requires use of a wide range of methods and is associated with significant costs.1-4 Sex differences are observed in diagnosis, prognosis, and treatment of cardiovascular diseases, particularly with regards to the incidence of risk factors, diastolic function, and the outcomes of interventions. 5-11 Lower diagnostic accuracy of the exercise stress test in women with CAD has been well-documented by a meta-analysis including more than 24,000 patients. It showed the sensitivity and specificity of 68% and 77%, respectively, in men, and only 61% and 70% in women.12 According to the concept of the ischemic cascade, a decrease in perfusion and impaired myocardial contractility precedes both ischemic electrocardiographic (ECG) changes and angina, which is consistent with the advantages ORIGINAL ARTICLEEffect of sex on the diagnostic efficacy of dobutamine stress echocardiography with early atropine administration in the detection of coronary artery disease

Objective:Despite premedication, anxiety in patients undergoing transesophageal echocardiography (TEE) is prevalent, often causing adverse physiological and psychological effects and contributing to decreased patient compliance. We aimed to evaluate the feasibility of cognitive–behavioral intervention (CBI) in patients undergoing TEE and to assess its impact on the severity of anxiety, patient’s and physician’s comfort, and administered dose of sedatives.Methods:Our study was designed as a prospective, single-center, single-blinded, case-controlled pilot study. The study group comprised 49 patients (26 men, 66±8 years old) referred for TEE. Before the examination, 26 randomly selected patients underwent CBI. Sedatives were administered, if necessary. After the examination, patient anxiety and patient’s and physician’s comfort were evaluated using dedicated questionnaires and scores. Intergroup comparison was performed using Student’s t-test for independent variables and Mann–Whitney U test and Pearson’s chi-square test or Fisher’s exact test for categorical variables.Results:The mean level of pre-TEE distress and anxiety were significantly lower in patients receiving CBI than in those without intervention (p=0.022). Furthermore, the application of CBI significantly reduced patient’s discomfort (p<0.001) and resulted in increased comfort of physician (p<0.001) during TEE. The need of sedative administration (31% vs. 91%, p<0.001) and its mean dose was significantly lower in patients receiving CBI (1.6±0.5 mg vs. 2.7±1.6 mg midazolam, p=0.009).Conclusions:CBI is feasible in patients undergoing TEE. It decreases patient’s anxiety and discomfort and increases physician’s comfort. It also results in reduced use of sedatives during the examination.

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Purpose The aim of this study is to assess the level of knowledge of safety and awareness about daily living in patients with cardiac implantable electronic devices (CIED) and potential impact upon anxiety and depression. Methods Data were collected in consecutive patients visiting pacemaker clinic for regular CIED follow-up. Demographic, clinical and psychological data were collected: Hospital Anxiety and Depression Scale-Modified (HADS-M) and a custom self-reported questionnaire was used (CIED-SRQ, 18 questions regarding daily activities, medical procedures and the safe use of electronic devices) to assess the knowledge regarding CIED. Dedicated questions referred to the preferences for CIED education channels in various age groups. Results We studied 186 patients (36,6% women, mean age 66,7±10,8) with CIED (63,5% pacemaker, 17,7% cardioverter defibrillator, 18,8% cardiac resynchronization therapy) in their first year following the implantation. In the CIED-SRQ the mean score of correct answers related to knowledge of CIED 13,25±2,86 (with 18 as the maximum possible score). The knowledge of CIED was correlated with the patients' level of education (p&lt;0,001) and inversely correlated with age (rho=−0443; p&lt;001). In the anxiety subscale of HADS-M, normal scores were noted in 75,8% patients, 13,5% cases were borderline, and abnormalities were observed in 10,7% patients. In the depression subscale, 70,4% were recognized as normal, 21,5% as borderline, and 8,1% as abnormal. As the knowledge of patients about CIED increased, there was a significant decrease in their depression level (rho=−0,149; p=0,042) and in the anxiety level (rho=−0,193; p=0,008). Anxiety level was higher in patients with CIED experiencing complications from the implantation (15,6% of patients in total experienced complications), both the mild (hematoma, bruising) and the severe (tamponade, lead dislocation, pneumothorax), when compared to the group without complications (p&lt;0,001). Conversely, no statistically significant difference between these groups was found as to their level of depression (p=0,051). The younger patients (≤64 years) were more often in favour of remote education on CIED (p=0,025), while the elder (≥65 years) most often preferred to be personally informed by the attending physician. Conclusions Lack of information and misinformation in patients with CIED may result in self-imposed restrictions, which could in turn result in higher levels of anxiety and depression. Patients experiencing CIED complications should be offered increased psychological care as well as more intense education about CIED, due to higher anxiety levels. Age influences the preferences for CIED education channels, thus educational approach must be individualized and age-appropriate. These findings may help health care professionals to provide holistic care to help patients manage to live with CIED and optimize postprocedural quality of life. Funding Acknowledgement Type of funding sources: None.