Different studies have attributed health benefits to Lactobacillus fermentum CECT 5716. However, the main problem associated with probiotics is their low resistance to environmental and technological factors. In this sense, capsules can provide a shell protection and a dosage form that is easy to swallow. For these reasons, the aim of this study was to evaluate the survival of Lactobacillus fermentum CECT 5716 in gelatin and gastro-resistant capsules during a period of 12 months at RT (room temperature) and 4 °C. The number of encapsulated cells remained relatively constant after six months of storage, since there were no statistically significant differences compared to the initial time (p > 0.05). Moreover, capsules are able to maintain a therapeutic level of bacteria (10 9 CFU/capsule) during the total period of storage. Gelatin capsules seem to protect worse probiotic than gastro-resistant (HPMC (hydroxy propyl methyl cellulose)) capsules. Furthermore, capsules stored at 4 °C show a low level of viability. These results suggest that HPMC capsules are an optimal dosage form for L. fermentum CECT 5716 and that the recommended condition of storage is room temperature rather than 4 °C.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.