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Introduction: A condition known as hyperthyroidism can lead to a wide range of health issues, including osteoporosis, oxidative liver damage, diabetes mellitus, as well as cardiovascular disease. Objective: To examine the detrimental effects of hyperthyroidism on the pancreatic structure of adult female albino rats. Materials and Methods: twenty-one adult virgin female albino rats were assigned to 2 groups; control and induction of hyperthyroidism. Serological analysis to assess thyroid functions, oxidative stress and lipid peroxidation analysis was carried out. Pancreatic samples were processed for light microscopic examination. Results: Hyperthyroidism caused both biochemical and histological changes on pancreas of adult female albino rats. The biochemical changes in the form of significant decreased in the thyroid stimulating hormone serum level, significant reduction in level of serum superoxide dismutase and the malondialdehyde level was significantly increased in the hyperthyroid rats. The histological changes were loss of its general architecture. The pancreatic acini appeared irregular, vacuolated and had dark nuclei. Some islets of Langerhans appeared shrunken and the acini did not have the normal smooth demarcation from the surface. Conclusion: Hyperthyroidism seriously affected the histological structure of the pancreas with subsequent disturbance in the biochemical markers.