A 46-year-old man with end-stage renal disease and renal cell carcinoma underwent 18F-FDG PET/CT for initial staging followed by 18F-PSMA-1007 PET/CT. Unlike 18F-FDG, which undergoes renal clearance, 18F-PSMA-1007 undergoes hepatobiliary clearance and thus generates superior quality images. 18F-PSMA-1007 PET/CT showed intense tracer-avid left renal mass lesion (FDG nonavid); lytic bone lesions (FDG avid) and single liver lesion (FDG nonavid). This case highlights the superiority of 18F-PSMA-1007 over 18F-FDG PET/CT in identifying primary lesion as well as metastatic sites in case of renal cell carcinoma even in the presence of end-stage renal disease.