Studies show that transsexuals experience prejudice and discrimination in their family and social relations, which can lead to experiences of suffering, anxiety and depression. There is evidence that a satisfactory attachment to an affective partner and the presence of an adequate personal support network act as protection against manifestations of stress, anxiety and depression, as well as being equally protective during the revelation and assumption of transsexuality. However, little is known about the support network and the quality of the affective-sexual relationships of transsexual people in transition. Based on these considerations, the present study aimed to investigate the family and affective-sexual relationships of transsexual people and to understand how these relationships are inserted in their social support network. This is a qualitative, descriptive-exploratory study, with a crosssectional design. As a methodological reference, the study of multiple cases was used, and as theoretical framework, the theory of the sexual scripts of Gagnon and Simon. Twelve people participated in the study. Six transsexual women and six transsexual men, aged between 19 and 58 years, accompanied by a specialized outpatient service linked to the public health system. Data collection was performed through the application of the following instruments: semi-structured interview script, with questions that sought to circumscribe the family network and social support, Genogram, Network Map. The data of the interview were submitted to content analysis in the thematic modality, and the interpretation of the results was based on the adopted theoretical framework. The results indicate ambiguity in the reaction of family members to the revelation of transsexuality, oscillating between acceptance and rejection. The affective relationships established by the participants tend to become fragile and undo in the face of the pressure of social judgment and the difficulty of recognizing the gender assumed. The process of constructing identity as a transsexual woman or man is marked by changes in conceptions of gender, sexuality and social roles, highlighting the social name and the struggle for legal recognition and obtaining new documents as a crucial facet in this process. The presence of a social support network, with the active participation of family and friends, seems to play a protective and welcoming role in the face of innumerable difficulties faced by transsexual people in their transition process, caused by prejudice and intolerance.