The aim of this study was to examine the structure of the placental villi associated with Zika virus at 28 weeks of pregnancy without another antecedent of illness and to be evaluated with light microscopy. Two groups of population of placental villi were taken of placenta study and placenta normal. The group studies proceed of placenta obtained at 37 weeks by caesarian delivery with fetal suffering. The placenta normal was obtained at 38 weeks with an increase of weight of woman pregnancy of 10 Kg both being processed according to previous works realized. The decidual region and stem villi showed infiltration of mononuclear cells. Stem villi were observed with thrombotic vessels, fibrinoid deposition, vascular obliteration, throphoblast necrosis and fibrosis. Zones of immature intermediate villi were seen suffering degenerative changes. Clear zones appeared in the stromal region of the placental villi. Mature intermediate villi have not bends and are absent of terminal villi. Numerous syncytial nodules are showed in zones of microinfarcts. Bad development of the ramifications of the placental villi is noted. These results indicate a destructive and generalized effect on the structure of the placental tree as also it has been affected by others viruses which damage the placenta contributing with fetal suffering or fetal death.