Introduction: In the scenario of heart diseases, especially cardiovascular diseases (CVD), there are several predictors of these diseases, including diseases related to oral health. Objective: It was to analyze through clinical studies the association of diseases of the oral cavity with cardiovascular diseases, to point out the main causes and treatments for future clinical studies. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from January 2022 to April 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: In line with the objective proposed in the present study, the results concluded that the association between chronic endodontic infection and CVD cannot be disregarded, although it is of limited quality evidence at the moment. Thus, clinical studies observed that the risk of diagnosing CVD in patients with chronic endodontic infection was 1.38 times those without infection. Furthermore, early childhood caries showed that the microbiome profile composed of Fusobacterium, Prevotella, Capnocytophaga, and Oribacterium were more abundant in the group with congenital heart disease than in the group without congenital heart disease. Also, the greater number of missing teeth was associated with an increased risk of a first acute myocardial infarction, and endodontic inflammatory disease may contribute as an independent risk factor for cardiovascular diseases.