Clinical and white cell counts response were evaluted in forty eight month old, well nourished infants, after the administration of an attenuated measles vaccine of the Schwaiz strain: fever was reported in 66.7% of them (temperature > 38°C), other symptoms were coryza (66.7^, cough (52.1 %», diarrhea (43.8^, rash (14.6^. Measles vaccine administration induced a drop in total leukocyte counts with increased absolute numbers of band cells.

Cell-mediated inmune response as a biological indicator of zinc deficiency: phenylketonuria as a study modelContradictory information exists in relation to zinc nutritional status in phenylketonuria. The objetive of this study was to confirm that there it is indirect evidence of zinc deficiency in patients with phenylketonuria as measured by the effect of zinc supplementation on cell-mediated inmune response. Delayed cutaneous hyper sensitivity readion and lymphopfoliferative response to phyohemagalutinin was determined in eight phenylketonuric children under specific nutritional management (low phenylalanine diet) before and after zinc acetate supplementation. Two of eight patients had a positive cutaneous response at admission and six became positive after zinc supplementation. This difference was statistically significant (p < 0.05 Mac Nemar test). Lymphoproliferative response to PHA was also significantly increased at the end of zinc supplementation, from a stimulation Index at PHA 5pg/culture 52.4 (I 1 -246] to 3 ] 5 (263-376) [mean, 1 SD range, p < 0.05 T-par). The improvement of cell mediated inmune response after zinc supplementation, suggests that zinc deficiency is present in phenylketonuric patients treated with low phenylalanine diets.[Key word it cell-mediated inmune response, zinc nutritional status, phenylketonuria, phenylalanine.) Arevato M. y cols. Revisla Chilena de PediatrlaMayo-Junio 1993