AbstrakAngka kejadian ruptur perineum pada primipara persalinan normal adalah sekitar 88,9%. Piper crocatum extract atau ekstrak daun sirih merah diketahui mempunyai kandungan kimia yang berefek antiseptik dan antibakteri. Sebagian besar persalinan normal di Kota Bengkulu mengalami ruptur spontan atau episiotomi. Dari 10 persalinan, ada 7 pasien yang mengalami robekan perineum dan kering rata-rata dalam 7 hari, dengan perawatan menggunakan iodin atau merendam/ cebok rebusan daun sirih. Tujuan penelitian ini adalah menilai efektivitas penyembuhan luka perineum ibu nifas dengan menggunakan daun sirih merah dan obat antiseptik. Metode penelitian quasi eksperimental, populasi ibu pospartum dengan luka perineum yang ditolong oleh bidan praktik mandiri. Sampel perlakuan 35 orang dan kelompok kontrol 35 orang. Sampel diambil secara accidental sampling. Waktu penelitian bulan Mei -Agustus 2012 di Kota Bengkulu. Variabel lainnya yaitu status kesehatan, obat antibiotik dan status gizi. Analisis menggunakan uji Mann _ Whitney Test. Hasil penelitian menunjukkan bahwa rata-rata lama penyembuhan luka perineum menggunakan infusum sirih merah adalah 2 _ 3 hari sedangkan pada kelompok obat antiseptik rata-rata lama penyembuhan 5 -6 hari, artinya bahwa daun sirih merah lebih efektif dibandingkan dengan iodine dalam perawatan luka perineum pada masa pospartum.Kata kunci: Perawatan perineum, postpartum, sirih merah AbstractThe incidence of perineal rupture in primiparous normal deliveries is 88.9%. Piper crocatum Extract or red betel leaf extract are known contained antiseptic and antibacterial effect. Mostly normal deliveries in Bengkulu City experienced spontaneous rupture or episiotomy. From 10 births, 7 patients experienced perineal laceration and were dry in 7 days by treatment using iodine or soak/ wiping with betel leaf decoction. The aim of this study was to determine the effectiveness of red betel leaf in healing perineal wound of postpartum mother in Independent Practice Midwife in Bengkulu City 2013.

There are several selection markers which are suitable for generating stably transfected Chinese hamster ovary (CHO) cell lines. Due to their different modes of action, each selection marker has its own optimal selection stringency in different host cells for obtaining high productivity. Using an internal ribosome entry site (IRES)-mediated tricistronic vector and a set of IRES variants with different strengths, the expression of five antibiotics resistance genes (ARGs) in CHO-K1 cells and dihydrofolate reductase (DHFR) in CHO DG44 cells is optimized to enhance the stringency of selection for high producing cells. There is an obvious optimal expression level for every selection marker, below or above which, the productivity is significantly lower. The enhanced productivity in ARG generated CHO K1 cells is due to selective integration of active site while the enhanced productivity in the amplified CHO DG44 cells results from increased gene copies. The high producing CHO K1 pools and clones generated using ARG exhibit better production stability than the amplified high producing CHO DG44 pools and clones. Loss of expression for the CHO K1 cell lines is due to loss of gene copies while for CHO DG44 is due to transcriptional silencing. mAb glycan profile also differed significantly between CHO K1 and CHO DG44 cell lines. These results would be helpful when developing optimized vectors for generating high mAb producing CHO cell lines.

Ilmu sosial mempunyai peranan penting dalam pengembangan kajian pendidikan Ilmu Pengetahuan Sosial (IPS), diantaranya seperti geografi, sejarah, sosiologi, ekonomi, psikologi, antropologi, dan politik. Tujuan penulisan artikel ini untuk mendeskripsikan bagaimana keterkaitan ilmu sosial dalam pengembangan kajian pendidikan Ilmu Pengetahuan Sosial (IPS). Desain penelitian yang digunakan pada penelitian ini berupa studi literatur. Strategi penelusuran data menggunakan berbagai buku, ebook, dan jurnal melalui platform google scholar dengan penelusuran melalui kata kunci terpilih. Hasil penelitian mendeskripsikan bahwa bidang ilmu sosial memiliki keterkaitan dalam kajian pendidikan Ilmu Pengetahuan Sosial (IPS). Materi Pendidikan Ilmu Pengetahuan Sosial (IPS) didasarkan atas dukungan konsep dari disiplin ilmu sosial, dalam bentuk tema-tema yang relevan dengan tujuan pembelajaran IPS diantaranya: waktu, keberlanjutan dan perubahan, manusia tempat dan lingkungan, produksi distribusi dan konsumsi, individu masyarakat dan institusi, budaya dan keragaman budaya, kekuasaan kewenangan dan pemerintahan, perkembangan individu dan identitas. Ilmu sosial berkontribusi untuk pengembangan program pendidikan Ilmu Pengetahuan Sosial (IPS).

Company’s financial condition reflected in the financial statements. However, there are many loopholes in the financial statements which can become a chance for the management and certain parties to commit fraud on the financial statements. This study aims to detect financial statement fraud as measured using fraud score model that occurred in issuers entered into the LQ-45 index in 2014-2016 with the use of six independent variables are financial stability, external pressure, financial target, nature of industry, ineffective monitoring and rationalization. This study using 27 emiten of LQ-45 index during 2014-2016. However, there are some data outlier that shall be removed, thus sample results obtained 66 data from 25 companies. Multiple linear regression analysis were used in this study. The results showed that the financial stability variables (SATA), nature of industry (RECEIVBLE), ineffective monitoring (IND) and rationalization (ITRENDLB) proved to be influential or have the capability to detect financial statement fraud. While the external pressure variables (DER) and financial target (ROA) are not able to detect the existence of financial statement fraud. Simultaneously all variables in this study were able to detect significantly financial statement fraud.