Student nurses are often exposed to various infections during their clinical education. Knowledge and compliance with standard precautions is essential to prevent hospital associated infections and protect patients as well as medical workers from exposure to infectious agents. This study assessed the knowledge and degree of compliance regarding standard precautions among student nurses in a government university in Samar, Philippines. A cross-sectional study was adopted for this investigation and data were collected over a period of one month from April 8 to May 7, 2012. Fifty eight student nurses who were enrolled in the university were asked to complete the self report questionnaires regarding standard precautions. Vast majority (89.7%) of the student nurses have good knowledge (students are satisfactorily well versed with the concepts of standard precautions) (m = 14.45/19) and high compliance (m = 3.59) of standard precautions. The use of mask has the highest degree of compliance (m = 3.95) while the use of eye goggles has the lowest degree of compliance (m = 3.19). Findings suggest no significant association between knowledge and compliance with standard precautions. Teaching approaches must be geared towards intensifying further the compliances especially with the use of other protective equipments such eye goggles and gloves. Furthermore, environment that models and promotes standard precaution practices should be developed by the faculty.