BackgroundSpontaneous miscarriage is the most common complication of pregnancy. Its psychological repercussions are widely documented but few studies have investigated its effect on the woman’s experience of a subsequent pregnancy.AimTo evaluate the impact of prior spontaneous miscarriage on the level of stress experienced by pregnant women during the first trimester of pregnancy.Design and settingCross-sectional, observational study between June and October 2021 in France.MethodA self-report questionnaire was distributed to women in the first trimester of pregnancy. Stress was assessed using the Antenatal Perceived Stress Inventory, to yield an overall score, and a score for three dimensions (medical and obstetric risks/fetal health; psychosocial changes; and the prospect of childbirth). Women with a history of prior spontaneous miscarriage and those without were compared.Results93 women were included ; 63 without and 30 with a history of prior spontaneous miscarriage. Prior spontaneous miscarriage was not associated with the overall score. The score for the dimension “medical and obstetric risks/fetal health” was significantly higher in women with prior spontaneous miscarriage (3.00±0.86 vs 2.34±0.80 ;β=0.61 (0.25–0.96) ;P=0.001). Prior spontaneous miscarriage was significantly associated with the items “the baby’s health” (P=0.048) and “the echography” (P=0.002).ConclusionThis study shows a significant impact of prior spontaneous miscarriage on the level of stress of pregnant women during the first trimester, particularly relating to the medical and obstetric risks/fetal health, underlining the need for appropriate psychological support to be provided to women who experience spontaneous miscarriage.