In the structure of causes of the end1stage chronic kidney disease is essential hypertension (EH) which takes the leading role. One of the pathogenic mechanisms of hypertensive nephropathy is a violation of intrarenal blood flow, which clinically manifesting with hyperfiltration. The objective: of the frequency of subclinical renal damage of patients with stage I EAH by water and salt loading and comparing these data with the standard criteria of essential nephropathy with hypertension. Patients and methods. The study involved 30 patients aged 27 to 59 years with diagnosed grade 1 essential hypertension who did not receive medical treatment and did not have the disease (lesions) of the kidneys. Mean albumin/creatin ratio of patients constituted 15,12±5,02 mg/g. According to the analysis of outpatient cards hypertension duration do not exceed during 5 years. All patients underwent 241hour blood pressure monitoring and determining the method RFR water and salt load (under patent Ukraine 42,860) [9]. The results of daily monitoring of blood pressure (DMAT) were patients divided into two groups: the 1st group included patients who had been diagnosted the I step and I stage of EH, it comprised 22 patients (73.3%). Second group included patients who had been diagnosted the II stage of EH – 8 patients (26.7%). Results. Subclinical kidney damage were found in 8 patients (26.7%) in determining the method of water-salt load. (RFR 10±2,01% in 8 patients (26.7%) 1st group and RFR 22,31±3,9% in 22 patients (73.3%) significant difference between groups (p<0.05). Among them, the state of hyperfiltration detected in 15 patients (50%) 281,55±40,66 ml/min per 1.73 m2. In eGFR 51,36±9,98 ml/min per 1.73 m2 had 6 people (20%), RFR was reduced and amounted to 11,02±6,65%. This shows that when increasing the blood pressure, kidney begins to lose its physiological reserve and its clinically possible to trace the transition state of hyperfiltration in decreased GFR. In determining GFR formula CKD-EPI reliable differences between groups were found. Conclusions. 1. Hypertension is an urgent problem and requires constant attention of the doctors of various specialties, complex problems that affect the incidence of kidney damage in the preclinical stage of hypertensive nephropathy. 2. The early hypertensive nephropathy criteria for the development of microalbuminuria may appear hyperfiltration and reduce renal functional reserve. 3. In EH patients with grade 1 hypertension, II stage, compared with patients with hypertension with I stage of kidney damage, were often observed and showed low RFR. 4. Using water1salt load for patients with EH and stages for the evaluation of kidney function can detect subclinical renal involvement, the development of microalbuminuria and reduced GFR.

To determine the functional state of the kidneys in patients with the I stage essential hypertension with different total risk of cardiovascular complications and to assess the effect of early medication (angiotensin II receptor blocker) on the dynamics of changes in the functional renal reserve.Material and Methods: This study included 80 patients with the established diagnosis -the I stage essential hypertension of the I-III grade in age from 18 to 60 years (28 women (35 %), the average age is 40,1 (35,0-56,0) years; men -57 (71%), average age -40,2 (37,0-53,0) years.A risk factor count was used to assess the overall risk of cardiovascular complications in hypertension. Functional renal reserve and endothelium-independent vasodilation of the brachial artery were defined.Statistical analysis was performed using SPSS Statistics.Results: In patients with high risk, the depleted and decreased functional renal reserve was most often detected, which was 55% of patients. It is also important to note that patients with even a low risk of cardiovascular complications have already had renal damage as a reduced or depleted functional renal reserve.Patients with a low risk of cardiovascular complications who had not started drug treatment on their first visit had a 2.3-fold (95% CI 1,048-4,896) higher relative risk of developing kidney damage in comparison with patients who had started medication therapy without delay.Conclusion: Diagnosis of functional renal reserve in patients with a low risk of developing cardiovascular complications in stage I arterial hypertension is an important component for predicting the further development of kidney damage and timely prevention of its progression. The early onset of drug treatment reduces the relative risk of developing kidney damage by 2.3 times in patients with arterial hypertension

Type 2 diabetes (T2D)chronic endocrine-metabolic disease that characterized by development of violations of all types of metabolism, especially, carbohydrate, and lesions of blood vessels, nerves, various organs and tissues [1].The most common cause of complications and disability in patients with T2D is cardiovascular disease (CVD), which is observed in more than half of the patients, and in 65 % of cases is the leading cause of death. The basis for CVD development is atherosclerotic