Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.

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Espcies reativas so continuamente produzidas pelo organismo, mas quando excedem a defesa antioxidante geram uma condio conhecida por estresse oxidativo, relacionado a vrias doenas crnico-degenerativas como o diabetes mellitus (DM). O DM caracterizado por hiperglicemia crnica, que resulta em desequilbrio metablico e dano tecidual. Assim, o aparecimento dessa patologia est altamente relacionado aos hbitos de vida e alimentares da populao, sendo de grande interesse a busca por suplementos alimentares que possam tambm atuar evitando ou diminuindo alteraes oxidativas em indivduos diabticos. Nesse contexto, suplementos alimentares constitudos por antioxidantes representam uma defesa muito eficiente de combate ao estresse oxidativo e, consequentemente, ao diabetes e suas complicaes. Dessa maneira, destaca-se ento, a conhecida ao antioxidante apresentada pela curcumina e tambm seus anlogos sintticos, sugerindo esses compostos para uso como promissores suplementos alimentares de forma a atuar como protetores do organismo.