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Introduction: Symptomatic interrogation (SI) provides a detailed investigation of each group of organs in the human body, correlating symptoms of different systems that are not always related to the main complaint. Despite its importance, IS is extensive, making its learning challenging for academics, reinforced by traditional and mechanistic teaching methods. Therefore, the objective of this research was to develop a didactic game that would enable better IS learning. Method: An iterative creation methodology was used, which is based on improving knowledge in a cycle and correcting possible game failures. This technique is divided into phases: communication, planning, modeling and construction. From this, it was decided to create a traditional low-cost game with wide access through cards. Results: The IS were divided into 10 large groups and divided by system or region, totaling 436 letters. Each technical term of the sign is followed by four descriptors with only one alternative corresponding to the questioned item. The template can be accessed through the QR code with your cell phones. The game is available for free to access and download. Conclusion: Technology is part of the daily life of all students, therefore, this tool should be used as a learning facilitator. Teaching through games brings speed and quality to learning, encouraging students to keep their attention, following the active teaching methodology model. So, this tool does not seek to replace the current teaching model, but to add. In future research, the aim is to develop a study that evaluates the change in academic performance before and after using this device.