A new series of rigid polymers was synthesized via radical copolymerization of N-phenylmaleimides, bearing pendant chromophores, with 4-vinylpyridine or styrene. Structural characterization was achieved by 'H NMR and 13C NMR spectroscopy, gel permeation chromatography (GPC), elemental analysis and differential scanning calorimetry (DSC). The thermal properties as well as the morphology of the investigated polymers at the air-water interface appear to be related to their rigidity. In spite of the presence of excellent mesogenic units, the polymers do not exhibit liquid crystalline behaviour. The 4-vinylpyridine copolymers form stable monolayers at the air-water interface. The attached chromophores electronically behave as monomers, as shown with in situ UV-VIS absorption spectroscopy. Brewster angle microscopy shows a spontaneous aggregation of these polymers into domains on a neutral subphase, whereas on an acidic subphase a more homogeneous monolayer is formed. The monolayers give Z-type transfer onto hydrophilic quartz. However, the chromophores seem to be oriented randomly at the substrate surface. The styrene copolymers do not form stable monolayers as a result of crystallization at the air-water interface.

Morphological changes of monolayers of two polymerizable pyridine amphiphiles upon complexation with Cu(II) ions at the air-water interface Werkman, P.J.; Schouten, A.J.; Noordegraaf, M.A.; Kimkes, P.; Sudhölter, E.J.R. IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of recordPublication date : 1998 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Werkman, P. J., Schouten, A. J., Noordegraaf, M. A., Kimkes, P., & Sudhölter, E. J. R. (1998). Morphological changes of monolayers of two polymerizable pyridine amphiphiles upon complexation with Cu(II) ions at the air-water interface. Langmuir, 14(1), 157 -164. DOI: 10.1021/la970576a Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. The monolayer behavior of two amphiphilic, diacetylenic units containing pyridine ligands at the airwater interface is studied by measuring the surface pressure-area isotherms and by Brewster angle microscopy (BAM). Both amphiphiles form stable monolayers at the air-water interface. The amphiphile containing an ester group shows a well-defined liquid-expanded (LE) to liquid-condensed (LC) phase transition, while the amphiphile with the amide group forms only a condensed monolayer film at 9.4°C. For both amphiphiles, addition of CuCl 2 to the subphase causes an increase of the surface pressure (Πc) at which the phase transition appears, suggesting the formation of a coordination complex at the airwater interface. Addition of Cu(ClO4)2 to the subphase instead of CuCl2 causes an even larger increase in Πc, indicating that more copper ions bind to the monolayer which results in a more charged monolayer. On a pure water subphase, Brewster angle microscopy of the monolayer of the ester-containing ligand shows the formation of spiral dendritic crystalline domains at the plateau in the isotherm near the solid state region. The formation of spiral crystalline domains indicates that the LC phase is L1′. The amidecontaining ligand, however, forms two-dimensional crystalline domains directly after spreading at the air-water interface, which are pushed together upon compression. No chiral crystalline domains were observed for this amphiphile indicating that the ester and amide amphiphile have a different LC phase. Both amphiphiles spread...

The Data Intelligence 4 Librarians course was developed by 3TU.Datacentrum at the end of 2011 to provide online resources and training for digital preservation practitioners, specifically for library staff. The course objectives are to transfer and exchange knowledge about data management, and to provide participants with the skills required to advise researchers or research groups on efficient and effective ways of adding value to their data. The paper describes the process of creating the course, the methodology and the results of the first pilot, which took place from February to June 2012. It also demonstrates the choices made during the design process and discusses the implications of the evaluation of the pilot course for further development: in particular, how the course might be expanded to more disciplines and other data repositories.

In deze blog de eerste resultaten van de dataverzameling van fase 2: De vragenljist

Prescribing dopamine replacement therapy remains the most common approach used by physicians who strive to support persons with Parkinson’s disease. In this viewpoint, we argue that instead of merely prescribing dopamine, healthcare professionals should particularly encourage and enable persons with Parkinson’s disease to draft their own personalized prescription of “hopamine”. The term hopamine is a self-invented neologism representing the uniquely personal set of hopes, desires, experiences, and skills of each individual with a dopamine deficit. As such, the concept of hopamine–as a reflection of the unique personal characteristics of each person with Parkinson’s disease— really supplements that of dopamine–as a reflection of each person’s unique physical characteristics. Whereas a prescription of dopamine replacement medication necessitates the diagnosed individual to lay his or her fate in the hands of medical professionals, adding a personalized dose of hopamine to the therapeutic mix empowers persons to self-manage daily life with Parkinson’s disease. In this viewpoint, we argue that hopamine is a prerequisite for personalized medicine and offer several practical recommendations for how medical professionals can introduce the concept of hopamine in daily clinical practice.