Changes in nailfold capillaroscopy in systemic sclerosis patients could be related to the disease severity. The aim of this study was to investigate whether patients with "late" scleroderma (SD) pattern have more organ involvement than patients with "early/active" SD pattern. Forty-six Argentinian patients (44 women and 2 men), with a diagnosis of systemic sclerosis, were distributed in two groups based on the presence of late and early/active patterns. Organ involvement was assessed as follows: pulmonary function by chest radiography, high-resolution chest tomography (HRCT), lung volume tests, and diffusing capacity for carbon monoxide (DLCO); esophageal involvement by manometry; and pulmonary arterial hypertension (PAH) by Doppler echocardiography and six-minute walk test. Honeycombing of the lungs evaluated by HRCT was more frequently present in patients with late pattern compared with early/active patients (p = 0.01). We also found statistically significant differences in lung volume tests (p = 0.03) and DLCO (p = 0.02) between the two SD pattern groups. Esophageal manometry showed a significantly higher frequency of motility disorders in the group with late pattern (p = 0.0024). In this study, patients with late pattern had higher frequency of pulmonary and esophageal involvement compared with patients with early/active pattern.

Background There is a lack of evidence regarding the benefits of β-blocker treatment after invasively managed acute myocardial infarction (MI) without reduced left ventricular ejection fraction (LVEF). Methods and results TREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fraction (REBOOT) trial is a pragmatic, controlled, prospective, randomized, open-label blinded endpoint (PROBE design) clinical trial testing the benefits of β-blocker maintenance therapy in patients discharged after MI with or without ST-segment elevation. Patients eligible for participation are those managed invasively during index hospitalization (coronary angiography), with LVEF >40%, and no history of heart failure (HF). At discharge, patients will be randomized 1:1 to β-blocker therapy (agent and dose according to treating physician) or no β-blocker therapy. The primary endpoint is a composite of all-cause death, nonfatal reinfarction, or HF hospitalization over a median follow-up period of 2.75 years (minimum 2 years, maximum 3 years). Key secondary endpoints include the incidence of the individual components of the primary composite endpoint, the incidence of cardiac death, and incidence of malignant ventricular arrhythmias or resuscitated cardiac arrest. The primary endpoint will be analyzed according to the intention-to-treat principle. Conclusion The REBOOT trial will provide robust evidence to guide the prescription of β-blockers to patients discharged after MI without reduced LVEF.

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As part of ARL’s Research Library Impact Framework initiative, a research team from the Texas Tech University (TTU) Libraries explored methods for assessing collections related to the study and research of diversity, equity, and inclusion (DEI) topics and their discoverability by users. DEI studies have increased in prominence on academic campuses along with calls to question privilege and power structures, making DEI collections assessment critical. The TTU Libraries undertook a two-part project that surveyed user needs, collections usage, cataloging and discoverability, and user behavior in searching for and evaluating DEI resources. While the researchers were not able to identify an effective method for assessing DEI in large-scale collections, key findings indicate the potential for partnering with women’s and gender studies and Mexican American and Latino/a studies and the need for increased attention on cataloging and metadata, particularly table of contents and abstract/summary fields. The research team identified that many users expressed uncertainty in searching and evaluating DEI resources and expressed interest in search enhancements for better filtering and more prominent website presence for DEI research help.

Playa lakes are a significant landform found in arid and semiarid climates. They provide water for wildlife, wetlands for waterfowl, flood control for municipalities, and many yield commercial quantities of evaporite minerals. This article discusses digital resources relating to playa lake research.