Six-body inelastic reactions are calculated microscopically including the full six-nucleon final state interaction. The total cross sections of gamma+ (6)He ( (6)Li)-->X are considered as examples. The Lorentz integral transform method and the effective interaction approach for the hyperspherical formalism are employed. While (6)Li has a single broad giant resonance peak, there are two well separated peaks for (6)He corresponding to the breakup of the neutron halo and the alpha core, respectively. The comparison with the few available experimental data is discussed.

De novo computational design of synthetic gene circuits that achieve well-defined target functions is a hard task. Existing, brute-force approaches run optimization algorithms on the structure and on the kinetic parameter values of the network. However, more direct rational methods for automatic circuit design are lacking. Focusing on digital synthetic gene circuits, we developed a methodology and a corresponding tool for in silico automatic design. For a given truth table that specifies a circuit's input–output relations, our algorithm generates and ranks several possible circuit schemes without the need for any optimization. Logic behavior is reproduced by the action of regulatory factors and chemicals on the promoters and on the ribosome binding sites of biological Boolean gates. Simulations of circuits with up to four inputs show a faithful and unequivocal truth table representation, even under parametric perturbations and stochastic noise. A comparison with already implemented circuits, in addition, reveals the potential for simpler designs with the same function. Therefore, we expect the method to help both in devising new circuits and in simplifying existing solutions.

The code is available on request from the authors.