Background: Recently, antitranspirant or radiation-reflective products have been studied in several crops to mitigate the negative effects of global warming in Mediterranean climates. Nevertheless, to our knowledge, there is a scarce availability of information studying their effects on blueberries and much less from applications of sunscreens elaborated based on a mixture of dicarboxylic acids. Methods: Controls and three treatments were performed in ‘Duke’ and ‘Star’ blueberries as follows: (i) control without water stress (T1 = 100% ETc); (ii) foliar application of sunscreen in plants without water stress (T2 = 100% ETc + sunscreen); (iii) water stress in plants without foliar application of sunscreen (T3 = 50% ETc); (iv) foliar application of the sunscreen in plants with water stress (T4 = 50% ETc + sunscreen). Stem water potential (Ψs), stomatal conductance (gs), yield, berry weight and berry total soluble solids were determined. (3) Results: As expected, the decrease in irrigation frequency in water stress treatments (T3 and T4) allowed for a decrease in the water applied at 25% compared to non-stressed plants (T1 and T2). This resulted in an increase in the Ψs on the days closest to harvest in both varieties, decreasing gs in blueberries plants subjected to water stress conditions. Sunscreen applications to Duke plants subjected to water stress (T4) induced higher total berry soluble solids than the treatments performed in non-stressed plants (T1 and T2). Sunscreen applications to Star plants subjected to water stress (T4) promoted similar gs levels and did not affect total soluble solids concerning irrigated plants (T1 and T2). (4) Conclusions: The results suggest that the response to water stress to sunscreen application based on dicarboxylic acid salts depended on the cultivar. Therefore, despite the novelty of this research, it is necessary to perform long-term studies to establish accurate conclusions.