Summary
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family that is known to play role as tumor suppressors. Here, we show that BRD7 is a component of the unfolded protein response (UPR) signaling through its ability to regulate X-box binding protein1 (XBP1) nuclear translocation. BRD7 interacts with the regulatory subunits of phosphatidyl-inositol3-kinase (PI3K) and increases the nuclear translocation of both p85α/β and XBP1s. Deficiency of BRD7 blocks the nuclear translocation of XBP1s. Furthermore, our in vivo studies have shown that BRD7 protein levels are reduced in the liver of obese mice, and reinstating BRD7 levels in the liver restores XBP1s nuclear translocation, improves glucose homeostasis, and ultimately reduces the blood glucose levels in the obese and diabetic mouse models.
The original version of this article contained an error in labeling Figure 4G. The top picture should be labeled as ''Ad-LacZ,'' and the bottom picture should be labeled as ''Ad-BRD7.
Costa (2021): Transcription-and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology, Autophagy,
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