Background: Antiretroviral therapy is a lifelong commitment that requires consistent intake of tablets to optimize health outcomes, attain and maintain viral suppression. Objective: We aimed to elicit predictors of treatment interruption amongst PLHIV and identify motivating factors influ- encing return to care. Method: We conducted a cross-sectional study using a mixed-method approach in four hospitals in Yaoundé. Sociodemo- graphic and clinical data were collected from ART registers. Using purposeful sampling, thirteen participants were enrolled for interviews. Quantitative data were analyzed using Epi-Info and Atlas-TI for qualitative analysis. Ethical clearance ap- proved by CBCHS-IRB. Results: A total of 271 participants records were assessed. The mean age was 33 years (SD±11years). Private facilities CASS and CMNB registered respectively 53 (19.6%) and 14 (5.2%) participants while CMA Nkomo and IPC had 114 (42.1%) and 90 (33.2%) participants. Most participants (75.3%) were females [OR 1.14; CI 0.78-1.66] compare with males. 78% had no viral load test results. Transport cost and stigmatization constituted the most prominent predictors of treatment interruption (47.5%) and (10.5%) respectively. Belief in the discovery of an eminent HIV cure and the desire to raise offspring motivated 30% and 61%, respectively to resume treatment. Conclusion: Structural barriers like exposed health facility, and dispensing ARVs in open spaces stigmatizes clients and increases odds of attrition. Attrition of patients on ART will be minimized through implementation of client centered ap- proaches like multiplying proxy ART pick points, devolving stable clients to community ARV model. Keywords: ART interruption; attrition; return to care; predictors; motivating factors; Cameroon.

Background: Antiretroviral therapy is a lifelong commitment that requires consistent intake of tablets to optimize health outcomes, attain and maintain viral suppression. Objective: We aimed to elicit predictors of treatment interruption amongst PLHIV and identify motivating factors influ- encing return to care. Method: We conducted a cross-sectional study using a mixed-method approach in four hospitals in Yaoundé. Sociodemo- graphic and clinical data were collected from ART registers. Using purposeful sampling, thirteen participants were enrolled for interviews. Quantitative data were analyzed using Epi-Info and Atlas-TI for qualitative analysis. Ethical clearance ap- proved by CBCHS-IRB. Results: A total of 271 participants records were assessed. The mean age was 33 years (SD±11years). Private facilities CASS and CMNB registered respectively 53 (19.6%) and 14 (5.2%) participants while CMA Nkomo and IPC had 114 (42.1%) and 90 (33.2%) participants. Most participants (75.3%) were females [OR 1.14; CI 0.78-1.66] compare with males. 78% had no viral load test results. Transport cost and stigmatization constituted the most prominent predictors of treatment interruption (47.5%) and (10.5%) respectively. Belief in the discovery of an eminent HIV cure and the desire to raise offspring motivated 30% and 61%, respectively to resume treatment. Conclusion: Structural barriers like exposed health facility, and dispensing ARVs in open spaces stigmatizes clients and increases odds of attrition. Attrition of patients on ART will be minimized through implementation of client centered ap- proaches like multiplying proxy ART pick points, devolving stable clients to community ARV model. Keywords: ART interruption; attrition; return to care; predictors; motivating factors; Cameroon.

Background: There is evidence that Quality of Life (QoL) of People Living with HIV/AIDS (PLHIV) has a significant role in ART retention, treatment adherence, and survival. As a result, QoL is becoming increasingly important for policy- makers, program implementers, and researchers. However, factors associated with QoL, in a culturally diverse country like Cameroon are unknown. Objective: We aimed to assess the QoL of PLHIV on ART and assess the extent to which physical, psychosocial, environ- mental, and spiritual factors drive QoL. Method: A cross-sectional study was conducted among 394 PLHIV aged >21 in North-West Cameroon from April to July 2019. Data were collected using WHO-QOL BREF questionnaire. Descriptive statistics, bivariate, and multivariate linear regression analyses were performed. Results: Majority (34.5%) of participants were in the age range of 41-50, with 73% females. The average QoL of the re- spondents was “good” with mean score of 3.57 on 5 and 71.4% agreed to have satisfactory QoL. Bivariate regression anal- yses revealed that all six proposed predictors were significantly associated with QoL. Psychological factors made the greatest impact (β = 0.213; p<0.003), followed by physical factors (β = 0.19; p<0.001). Conclusion: PLHIV fairly agreed to have good QoL. The QoL was driven by mainly psychological and physical factors and not level of independence. However, the mean score perceptions for the investigated domains were low. Mental health ser- vices should consider these predictors when designing strategies to improve the QoL of PLHIV. While this study provides useful insights, other possible drivers of QoL among PLHIV should be investigated. Keywords: Quality of life and associated factors; HIV patients; antiretroviral therapy; Cameroon.

Background: There is evidence that Quality of Life (QoL) of People Living with HIV/AIDS (PLHIV) has a significant role in ART retention, treatment adherence, and survival. As a result, QoL is becoming increasingly important for policy- makers, program implementers, and researchers. However, factors associated with QoL, in a culturally diverse country like Cameroon are unknown. Objective: We aimed to assess the QoL of PLHIV on ART and assess the extent to which physical, psychosocial, environ- mental, and spiritual factors drive QoL. Method: A cross-sectional study was conducted among 394 PLHIV aged >21 in North-West Cameroon from April to July 2019. Data were collected using WHO-QOL BREF questionnaire. Descriptive statistics, bivariate, and multivariate linear regression analyses were performed. Results: Majority (34.5%) of participants were in the age range of 41-50, with 73% females. The average QoL of the re- spondents was “good” with mean score of 3.57 on 5 and 71.4% agreed to have satisfactory QoL. Bivariate regression anal- yses revealed that all six proposed predictors were significantly associated with QoL. Psychological factors made the greatest impact (β = 0.213; p<0.003), followed by physical factors (β = 0.19; p<0.001). Conclusion: PLHIV fairly agreed to have good QoL. The QoL was driven by mainly psychological and physical factors and not level of independence. However, the mean score perceptions for the investigated domains were low. Mental health ser- vices should consider these predictors when designing strategies to improve the QoL of PLHIV. While this study provides useful insights, other possible drivers of QoL among PLHIV should be investigated. Keywords: Quality of life and associated factors; HIV patients; antiretroviral therapy; Cameroon.

Introduction Breast cancer (BC) is the most prominent cancer in females and is cited as a leading cause of cancer-related mortality in women worldwide. We aimed to determine factors influencing adherence to surgery and chemotherapy in women with BC in Mbingo Baptist Hospital (MBH). Methods we conducted a cross-sectional study in the MBH-Cameroon. Purposeful sampling was used to select participants for investigation. A structured questionnaire was applied to 82 women on chemotherapy in the oncology unit. Socio-demographic, clinical, and therapeutic data were collected from participants. The Morisky Medication Scale (MMS) was used to assess the patient's motivation and knowledge while the Adherence Starts with Knowledge (ASK12) questionnaire was used to measure the patient's barriers to treatment. SPSS was used for data analysis. Results the mean age was 46.37 (SD 11 years). Most participants (67.1%) were in the group of (25-50 years). The majority (75.6%) of respondents attended at least primary school. The results showed that adherence to surgery and chemotherapy is low 44% and 56.1% respectively, and this was greatly influenced by treatment delay (P = 0.034), missed chemotherapy dose without medical indication (P=0.029), patient's motivation, and knowledge towards their disease and treatment (P=0.0001 and P=0.0001), respectively. Conclusion our results revealed that adherence to surgery and chemotherapy among women with BC in MBH is low and is driven by the patient´s motivation, knowledge about the disease, and treatment.