age at successive deliveries and at last delivery (positively correlated); height and stature (weight:height) at biopsy (younger women were taller and slimmer); and concentrations of oestrogen and progesterone receptors in the tumour.4 Possibly less direct indicators of age were also positively related: the number of children, how long she had nursed them, whether she had a sister with breast cancer, and the time between discovery of disease and biopsy.To separate analytically the effects of aging from other causes that alter the age at diagnosis of breast cancer, data are needed on agematched women of similar origins who do not have cancer.We thank Dr Robert L Egan for access to his data files, which permitted independent verification of parts of our data. Case reportIn August 1980 an 8-year-old girl was visited by a social worker in connection with a forthcoming holiday. Her family was well known to the social services department owing to previous child neglect. The girl was noted to have extensive linear and blistering skin lesions, which the social worker thought might have been inflicted by the father with a whip or a lighted cigarette. The child and her parents were referred to hospital the same day. The parents stated that skin lesions had been present for 10 days, and the father repeatedly and indignantly protested that he had not touched her. The child denied any ill treatment.The lesions were most prominent on the trunk, especially the back and shoulders (figure), but were also present on the forehead, hands, arms, thighs, and lower legs. Many lesions were linear with dusky redness consistent with whip marks, but closer inspection showed areas of brown hyperpigmentation. The lesions were recognised as those of phytophotodermatitis. It transpired that during recent sunny weather she had been playing on waste ground near her home wearing only her underpants. In view of the medicolegal aspects of the case a photographer subsequently visited the area with the child and photographed large quantities of wild parsnip (Pastanaca sativa), which was in full flower and starting to set seed. CommentWild parsnip is a common yellow-flowered umbelliferous plant growing to a height of about one metre. It contains at least three furocoumarins (psoralens)-namely, 5-methoxypsoralen, 8-methoxypsoralen, and 5-isopentenyloxypsoralenl-which act as photosensit sers. Development of lesions depends on exposure of the skin both to furocoumarins in the plant sap and to adequate amounts of longwave ultraviolet irradiation.a The reaction is a phototoxic one and is not dependent on previous allergic sensitisation.3 The severity of skin lesions ranges from erythema through oedema to blistering in severe cases.' 4 Hyperpigmentation develops within a few days and is diagnostically helpful.4Extensive skin lesions caused by phytophotodermatitis.Furocoumarins are usually most abundant in mature plants that have flowered and set seed,' as in this instance. The usual time of presentation is in July and August, when the plants are fully dev...
chotropic drug use in non-psychiatric departments of three European university hospitals. Nord J Psychiatry 2000;54:61-65. Oslo. ISSN 0803-9488.The use of psychotropic drugs in the university hospitals in Tartu, Estonia; Huddinge, Sweden; and Badajoz, Spain, were studied, using the defined daily doses per 100 bed-days (DDD/100 bed-days) method. The total amount of drugs used in the surgical and medical departments was 50 DDD/100 bed-days in Huddinge, versus 33 and 14 DDD/100 bed-days in Tartu and Badajoz, respectively. Barbiturates accounted for 35% of all psychotropics in Tartu but were practically not used in Huddinge. In contrast, antidepressants were practically not used in Tartu. The use of psychotropic drugs in the intensive care units was highest in Huddinge (320 DDD/100 bed-days), compared with Tartu and Badajoz (177 and 96 DDD/100 bed-days, respectively). The frequency of psychotropic drug use were strikingly different in the three hospitals studied.• Drug utilization, Psychotropic drugs.
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