Context: Spain was at the epicenter of the pandemic. Health centers across Spanish territory were not able to respond to non-emergency enquiries, leaving community pharmacies as the first point of patient’s contact. Aims: To investigate the impact of COVID-19 on the mental and physical health of community pharmacy teams across Spain. Methods: A cross-sectional observational study was performed with community pharmacy professionals throughout Spain. A questionnaire designed by our collaborator from the United Kingdom was adapted to the Spanish population and launched between October 2020 and February 2021. Results: A total of 98 participants responded to the questionnaire. The survey showed an 80% increase in workload. The pandemic had negatively impacted the well-being of community pharmacy professionals. The survey indicated a national shortage of medicines and personal protective equipment across Spain, particularly during the first peak. To adapt to this pandora’s box of COVID-19, 96% of the pharmacies changed their settings to improve patients and staff’s safety. Most of these changes were self-financed by the pharmacy owner. The pharmacists kept up to date with information released from the pharmacists’ college, General Pharmaceutical Council and the Spanish Society of Community Pharmacists. The Public domain purchased more (79%) immune booster supplements. Conclusions: Community pharmacy professionals have faced tremendous mental, physical and professional pressure in providing adequate personal protective equipment and medication supply to their communities. They have provided more pharmaceutical services during the crisis, although they have not been recognized as essential workers by the healthcare system.

Background: Impaired renal function (IRF) in patients with diabetes impose a significant health burden. This study evaluates the association of three diagnostic categories of with a reduction on glomerular filtration rate Methods: We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes (ADA) criteria. IRF was defined as having a glomerular filtration rate < 60 mL/min/1.73 m2. Incidence rate of IRF according to prediabetes and diagnostic categories of prediabetes as well as Kaplan Meir figures were calculated. Hazard ratios (HR) for the association of the prediabetes diagnostic categories of prediabetes with IRF, adjusting for potential confounders, were estimated by Cox regression models.Results: IRF Incidence rate per 100 person-years in subjects without prediabetes was 1.72 (95% confidence interval [CI]: 1.34-2.21) and 1.79 (95%CI: 1.45-2.20) for those with prediabetes stage, log rank test p= 0.84. Prediabetes was associated with an adjusted HR of IRF onset of 0.76 (95% CI: 0. 54-1.07). Corresponding HR for diagnostic categories were 0.68 (95%CI:0.40-1.15) for those with both altered parameters, 0.68 (95%CI: 00.40-1.15) for those with only impaired HbA1c and 1.12 (95%CI: 0.68-1.85) for those with only impaired FPG. Conclusions: The present study reflects an overall trend towards a slightly decreased risk of IRF onset associated to prediabetes except for individuals with only isolated impaired FPG. Further studies are warranted to fully assess the renal progression of each group.