SummaryThere is considerable concern over declines in insect pollinator communities and potential impacts on the pollination of crops and wildflowers [1][2][3][4] . Among the multiple pressures facing pollinators [2][3][4] , decreasing floral resources due to habitat loss and degradation has been suggested as a key contributing factor 2-8 . However, a lack of quantitative data has hampered testing for historical changes in floral resources. Here we show that overall floral rewards can be estimated at a national scale by combining vegetation surveys and direct nectar measurements. We find evidence for substantial losses in nectar resources in England and Wales between the 1930s and 1970s; however, total nectar provision in Great Britain as a whole had stabilised by 1978, and increased from 1998 to 2007. These findings concur with trends in pollinator diversity, which declined in the mid-20th century 9 but stabilised more recently 10 . The diversity of nectar sources declined from 1978 to 1990 but stabilised thereafter at low levels, with four plant species accounting for over 50% of national nectar provision in 2007. Calcareous grassland, broadleaved woodland and neutral grassland are the habitats that produce the greatest amount of nectar per unit area from the most diverse sources, whereas arable land is the poorest in both respects. While agrienvironment schemes add resources to arable landscapes, their national contribution is low. Due to
Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
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