The role of rifting in the formation of the recent structure of the Mongolia-Okhotsk orogen is extremely high, but it is still underestimated with regard to flanks of the Dzhagda segment of this orogen. Current researches refer to a combination of physical and chemical processes in the depth of the lithosphere, as well as interactions between the Izanagi, Eurasian and Pacific plates as explanations of repeated rifting events in East Asia. Upwelling of the asthenosphere due to significant differences in the lithosphere thickness (150-200 km under cratons, and only 100 km under orogenic belts) was viewed as a cause of rifting. It was assumed that rifting was controlled by mantle plumes, volcanism and heat regime. Structures bordering the Mongolia-Okhotsk orogen from north and south were considered as superimposed or marginal troughs. Recent studies have revealed numerous riftogenic Late Mesozoic structures in the Central Asian orogenic belt, which resulted from the collision of the Siberian and North Chinese cratons. New geological survey and geochemical data on volcanites confirmed the riftogenic origin of the Zeya-Uda (or Uda) and Nora-Selemdzha troughs bordering the Mongolia-Okhotsk orogen from north and south, respectively ( Fig. 1, and 2). Geology and geophysics of those troughs has been described. It is noted that riftogenic volcanites formed later in the east than those in the west. The Late Mesozoic rifting is widely manifested in North Eastern Asia across the area exceeding two million square kilometers, from Lake Baikal to the Sikhote-Alin region (west to east) and from the Southern Yakutia basins to North China (north to south). It is evidenced by intra-continental rifts of various trends, volcanic provinces and extension structures along large strike-slip faults [Ren et al., 2002]. The Uda and Nora-Selemdzha marginal troughs located along the Dzhagda segment of the Mongolia-Okhotsk orogen give evidence that compression was replaced by extension in the study area. Rifting structures may be due to physical and chemical processes, the development of plumes [Yarmolyuk et al., 2000], as well as the interaction between the Pacific and Eurasian lithospheric plates. Volcanic activity took place earlier in the west and then propagated to the east due to the shifting of the subduction zone in this direction. This paper analyzes regional and global geological events on the basis of new drilling data and the geochronological dating of volcanites. It describes the Late Mesozoic stage of rifting at the flanks of the Dzhagda segment of the Mongolia-Okhotsk collisional orogen. P a l e o g e o d y n a m i c s RESEARCH ARTICLEДля цитирования: Кириллова Г.Л. Позднемезозойский рифтогенез на флангах Джагдинского звена Монголо-Охотского коллизионного орогена: глобальные и региональные аспекты // Геодинамика и тектонофизика.

Plate tectonics is the kinematic theory that describes the large-scale n1otions and events of the outermost shell of the solid Earth in terms of the relative motions and interactions of large, rigid, interlocking fragments of lithosphere called tectonic plates. Plates fo1m and disappear incrementally over tin1e as a result of tectonic processes. There arc cun·ently about a dozen n1ajor plates on the surface of the Earth, and 1nany tninor ones. The present-day configuration of tectonic plates is illustrated in Figure 7 .1. As the interlocking plates •nove relative to each other, they interact at plate boundaries, where adjacent plates collide, diverge, or slide past each other. The interactions of plates result in a variety of observable surface phenomena, including the occurrence of earthquakes and the formation of large-scale surface features such as mountains, sedimentary basins, volcanoes, island arcs, and deep ocean trenches. In tum, the appearance of these phenon1ena and surface features indicates the location of plate boundaries. For a detailed review of the theory of plate tectonics, consult Wessel and Muller (2007).A plate-tectonic reconstruction is the calculation of positions and orientations of tectonic plates at an instant in the history of the Earth. The visualization of reconstructions is a valuable tool for understanding the evolution of the systems and processes of the Earth's surface and near subsurface. Geological and geophysical features may be "embedded" in the sin1ulated plates, to be reconstructed along \Vith the plates, enabling a researcher to trace the n1otions of these features tlrrough time. Even a single static reconstruction can reveal an illuminating configuration of surface or subsurface features. A time-sequence of reconstructions may be used to anitnate the motions of plates, producing kincn1atic and other tin1e-derivative infonnation, \vhich in tum can provide insight into the geodynamic processes of the near subsurface and deeper Earth.Plate-tectonic reconstructions are useful in a variety of contexts, such as research in geology, geophysics, and paleobiology; exploration for mineral and hydrocarbon 95

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We have investigated the functional characteristics of term human placental villous explants kept in long-term (7-11 days) culture. Fragments of placental villous tissue (approximately 5-10 mg wet wt) were cultured in supplemented CMRL-1066 culture medium for up to 11 days. After the first day of culture, the syncytiotrophoblast appeared vacuolated and eventually degenerated. However, a new syncytiotrophoblast developed by day 4, being indistinguishable from that of a fresh placenta by 11 days. Release of human chorionic gonadotrophin increased and activity of lactate dehydrogenase in culture medium decreased with culture time. Transport variables were measured over the first 7 days of culture. Basal (86)Rb efflux was reduced with time in culture and was inhibited by Ba2+, suggesting the efflux was mediated by K+ channels. At all stages of culture, (86)Rb efflux was stimulated by ATP, hyposmotic medium, and ANG II. A complex pattern of efflux changes with culture time and type of stimulator was observed, suggesting that several compartments of the tissue contributed to stimulated efflux. This culture system provides opportunities for studies of chronic regulation of placental function.

Summary Background National Institute for Health and Care Excellence guidance recommends assessment of psychological and social well‐being in people with psoriasis. Objectives To screen systematically for depression and anxiety in patients with psoriasis in routine clinical practice and to identify at‐risk groups for psychiatric morbidity. Methods Consecutive patients attending a single, tertiary centre over a 10‐month period were invited to complete the Patient Health Questionnaire Depression Scale (PHQ‐9), Generalized Anxiety Disorder Scale (GAD‐7) and Dermatology Life Quality Index (DLQI) as part of IMPARTS: Integrating Mental and Physical Healthcare: Research, Training and Services. Information on demographics, treatment and clinical disease severity was collated from electronic patient records. Regression models were used to identify at‐risk groups for psychiatric morbidity. Results Of 607 patients included (56·2% on biologics), 9·9% (95% confidence interval 7·5–12·3%) screened positive for major depressive disorder (MDD) and 13·1% (79/604) (95% confidence interval 10·4–15·8%) for generalized anxiety disorder (GAD; GAD‐7 score > 9). Suicidal ideation was reported in 35% of those with MDD; DLQI was < 10 in 38·3% and 45·6% cases of MDD and GAD, respectively. After adjusting for covariates, the risk of MDD or GAD was significantly higher in women and those with severe clinical disease, psoriatic arthritis and previous depression/anxiety. The risk of GAD was significantly increased with Asian ethnicity and use of topical treatments only. Conclusions Systematic screening for anxiety and depression identifies clinically important levels of depression and anxiety that may be missed using DLQI data alone. Women and those with severe disease, psoriatic arthritis and/or a prior history of psychiatric morbidity may be at particular risk.