Noxious cutaneous stimulation of anterior sites on Aplysia californica causes withdrawal and turning followed by escape locomotion. Stimulation of anterior sites causes significantly larger turning responses than does stimulation of posterior sites, so that escape locomotion is always directed away from a site of 'attack'. Later phases of escape locomotion are often the same, regardless of the site of the triggering stimulus. The defensive secretions, ink and opaline, are directed along the anterior-posterior axis at the source of noxious stimulation. Ink and opaline ejections are directed to the front or back of the animal by characteristic responses of the siphon, mantle, and parapodia. Ink and opaline are ejected by a series of coordinated pumping movements of the mantle, gill, and parapodia that closely resemble triggered 'respiratory pumping' or 'Interneuron II' episodes (Kupfermann and Kandel 1969; Byrne and Koester 1978; Hening 1982). The directed ejection of secretions from the mantle cavity in response to noxious stimulation suggests a number of potential defensive functions for these secretions including aggressive retaliation, startle display, diversion, and alarm signalling (Edmunds 1975). Taken together, our results and others' suggest an integrated scheme for the functional organization of overt defensive behavior in Aplysia, and begin to suggest testable hypotheses about the integration of defensive responses on the cellular level in this animal.

In this paper we present results from an extensive survey of United Kingdom (UK) university academics investigating satisfaction with senior managers and university governance: the Senior Management Survey (SMS). 5,888 academic staff across the United Kingdom Higher Education (HE) sector completed the survey, and results were used to construct a league table of staff satisfaction with management. This table is a stark indictment of the current state of the UK HE sector, showing a mean satisfaction score of 10.54%. The SMS also collected qualitative data, and we extend the league table's insights using this data. Thematic analysis revealed seven major themes: the dominance and brutality of metrics; excessive workload; governance and accountability; perpetual change; vanity projects; the silenced academic; work and mental health. We conclude with a discussion of how this statactivist research can be used to bring about change in management and governance of UK HE.

Nonassociative training with a noxious unconditioned stimulus (US) applied to the head or tail of freely moving Aplysia caused a qualitative change in siphon responses to midbody test stimulation, so that the midbody test responses came to resemble the unconditioned siphon response (UR) to the US when tested 1 d after exposure to the US. Such a nonassociative, US-induced transformation of test responses into responses resembling the UR has traditionally been termed "pseudoconditioning." Short-term pseudoconditioning was compared to sensitization and to habituation in a reduced preparation that used a photocell to distinguish "head-type" siphon responses from qualitatively different "tail-type" responses. Transformation of test responses (pseudoconditioning) was observed only when the type of preexisting alpha response to the midbody test stimulus was different from the UR. Sensitization, defined as a US-induced enhancement of the alpha response to the test stimulus, was observed when the initial alpha response and the UR were of the same type. General sensory facilitation was excluded as a critical mechanism for pseudoconditioning by the observation that the same midbody test response could be transformed to either a head-type or tail-type response, depending on the site of the US, and by the observation that simply increasing the intensity of the midbody test stimulus in the absence of a head or tail US did not produce similar response transformations. These studies demonstrate pseudoconditioning in a preparation amenable to analysis at the level of identified neurons, and draw attention to a distinctive and widespread form of behavioral modifiability that has been neglected by investigators of learning.

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Lowering serum cholesterol, which appears to reduce mortality due to cardiovascular disease, may also increase mortality due to violent causes, including homicide, suicide and accidents. In animal research, lowering cholesterol has been linked to increased aggression. These findings suggest a Darwinian interpretation. During evolutionary history a reduction in serum cholesterol was probably invariably associated with famine. In times of famine an increased propensity for aggression may be adaptive as the struggle for survival intensifies. Evidence suggests that lowering cholesterol reduces CNS serotonergic activity and reduced serotonergic activity is known to effect an increase in impulsive, aggressive behavior. Lowered serum cholesterol may then function as an internal signal of threatened starvation, adaptively increasing aggressive behavior through effects on serotonergic activity.