Children with SCD who are exposed to ETS have a higher risk of sickle cell crises requiring hospitalization than do those not exposed, independent of other factors known to increase the frequency of sickle cell crises. Decreasing the exposure of these children to ETS could reduce morbidity and may provide cost savings.

In the present study the frequency and magnitude of the release of 5-Hydroxyindoleacetic Acid (5-HIAA) was measured from the anterior hypothalamus of ovariectomized (OVX) and OVX rats treated with estradiol (E2). Female, Holtzman strain rats were maintained on a photoperiod of 14 H light from 0100 to 1500 H and experiments performed from 0900 to 1700 H. Animals exhibiting four-day estrous cycles (250-300 gms) were OVX (20 days recovery) and a push-pull-cannula (PPC) implanted and stereotaxically aimed at the SCN region in the anterior hypothalamus. Following a 7-10 day recovery push-pull-perfusion (PPP) experiments were performed on either OVX females or on OVX females in which a silastic E2 implant (150 micrograms E2/ml. sesame oil), was placed sc 48 H prior to PPP. In other experiments progesterone (P4) was perfused in a pulsatile manner over the SCN region of the anterior hypothalamus. The overall average 5-HIAA release in the OVX treated rats (548 +/- 358 pg/10 min.) was similar to that in the OVX E2 group (694 +/- 148 pg/10 min). The average period of 5-HIAA release was (48.2 +/- 5.5 min) in the OVX group and (56.0 +/- 9.8 min) in the OVX E2 group. These results indicate that exposure of long term OVX rats (20 days) to E2 has no effect on the release or period of 5-HIAA release from serotonergic terminals concentrated in the SCN of the anterior hypothalamus.(ABSTRACT TRUNCATED AT 250 WORDS)

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Telemental health technology is a feasible tool for providing behavioral healthcare in rural areas. However, there is scant literature about implementing this technology within Indigenous populations. The Aleutian Pribilof Islands Association is an urban‐based Tribal Health Organization in Alaska tasked with providing behavioral health services to remote Unangax̂ communities. To expand telemental health services, a formative program evaluation was conducted to examine the acceptability of and barriers to implementing telemental health. Using a qualitative approach, five individuals with lived experience in the same community were interviewed using a semi‐structured format. Data were analyzed using critical thematic analysis and situated within the context of historical trauma. Five themes were constructed that showed broken trust as the primary barrier to services, despite the substantial obstacles related to communications infrastructure. When situated within the context of historical trauma, the results show how colonization spurred and has maintained broken trust. The clinical, research, and policy implications resulting from this study point to the need for decolonization and integration of culture in behavioral health services. These findings can be informative for organizations and providers seeking to implement telemental health in Indigenous communities.