In this article, the optimization of the modified U-Net neural network model extended with fuzzy layers has been studied with the usage of Grid search and Keras tuner. The article is a continuation of previous work where the model is suggested and explored. From one point of view, the research is focused on the optimization of Fuzzy Layers embedded in the U-Net model in order to find the better neural network architecture for nuclei segmentation in the research work in BioMed Varna R&D ecosystem for the segmentation of cellular nuclei. At the same time from a global perspective, this experiment is a part of the bigger one for the searching of new neural network architecture design techniques.
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